新辅助化疗治疗乳腺癌的不同方案比较研究  

Evaluation of two different regimens as neoadjuvant chemotherapy for breast cancer

作　　者：胡虞乾[1] 邱超学[1] 廖文胜[1] 杨威[1] 刘耀星[1] 范平[1] 廖明成[1] 邓水柱[1] 

机构地区：[1]广西壮族自治区南溪山医院普外一科,桂林541002

出　　处：《医师进修杂志（外科版）》2005年第5期16-18,共3页

摘　　要：目的比较两种不同新辅助化疗方案治疗进展期乳腺癌的疗效。方法1999年9月～2004年9月用CF、FAC方案新辅助化疗治疗Ⅱ、Ⅲ期乳腺癌30例。CF方案:甲酰四氢叶酸钙(CF)300mg/d,第1～5天,持续4h静脉滴注,氟尿嘧啶(5-FU)500mg/d,第1～5天,持续4h静脉滴注,4周为1个周期;FAC方案:5-FU500mg/d,第1、第8日,持续4h静脉滴注,阿霉素(ADM)40mg/m2,第1天静脉注射,环磷酰胺(CTX)500mg/m2,第1、第8天静脉注射,4周为1个周期。均完成2个周期后评价疗效。结果CF组总有效率为66.7%(10/15),其中临床完全缓解(CCR)1例,部分缓解(PR)9例,无变化(NC)5例。FAC组总有效率为40%(6/15),其中CCR1例,PR5例,NC9例。两组中Ⅱ期疗效高于Ⅲ期,CF方案组与FAC方案组疗效比较有统计学差异(P<0.05)。结论两组新辅助化疗方案对乳腺癌均有效,毒副反应均可耐受,CF组疗效高于FAC组。Objective\ To compare the efficacy of two different regimens as neoadjuvant chemotherapy for breast cancer in progress stage. Methods Thirty patients with stage Ⅱ and Ⅲ breast cancer were treated with either calcium folinate (CF) and 5-fluorouracil (5-FU ) or 5-FU,adriamycin(ADM), and cyclophosphamide(CTX) regimens for 2 cycles every four weeks. Clinical responses were assessed after 2 cycles of neoadjuvant chemotherapy. Patients in CF scheme received 5-FU 500 mg/d by 4 hours continuous infusion from day 1 to day 5, CF 300 mg/d by 4 hours continuous infusion from day 1 to day 5. Patients assigned to the FAC scheme received 5-FU 500 mg/d by 4 hours continuous infusion on day 1 and day 8, ADM 40 mg/m^2 by intravenous injection on day 1, CTX 500 mg/m^2 by intravenous injection on day 1 and day 8. Results For advanced breast cancer, the overall response rate was 66.7%(10/15) in CF scheme and 40.0%(6/15) in FAC scheme. Patient showed clinical complete response in 1, partial response in 9 and no change in 5 after the CF schems therapy, while patient showed complete response in 1, partial response in 5 and no change in 9 after FAC scheme therapy. A proportion of response rate in stage Ⅱ was higher than that of stage Ⅲ. The efficacy in CF group was significantly higher than that of FAC group (P<0.05) Conclusions Neoadjuvant chemotherapy is effective to advanced breast cancer, and the side effects and toxicity is tolerable. The efficacy in CF scheme is better than that of FAC scheme.

关 键 词：化疗 治疗 乳腺癌 比较研究 CF方案 FAC方案 

分 类 号：R737.9[医药卫生—肿瘤]