听神经瘤TGF-β_1的表达及其与肿瘤细胞增殖的相关性研究  

Expression of TGF-β_1 in Acoustic Neuroma and Its Correlation with Tumor Cell Proliferation

作　　者：詹洪峰[1] 契燕燕[1] 张焱[1] 

机构地区：[1]江苏大学附属人民医院肿瘤科,江苏镇江212002

出　　处：《河南肿瘤学杂志》2005年第3期165-167,共3页Henan Journal of Oncology

摘　　要：目的探讨人听神经瘤中转化生长因子β1与肿瘤细胞增殖的相关性。方法应用免疫组织化学方法检测69例听神经瘤转化生长因子β1和增殖细胞核抗原的表达。分析转化生长因子β1与肿瘤细胞增殖指数之间的相关性。结果在实性组和复发组中,TGFβ1与PCNA指数有明显正相关,在囊变组中TGFβ1与PCNA指数无相关性。在以肿瘤直径为分组依据的各组听神经瘤之间,TGFβ1、PCNA的差异没有显著性,组内TGFβ1、PCNA之间无相关性。结论在实性和复发听神经瘤中,TGFβ1与肿瘤细胞增殖有一定关系,可作为预测肿瘤进展和复发的重要因子。Objective To study the correlation of TGF-β1 with tumor cell proliferation.Methods Expression of TGF-β 1 and PCNA was detected by immunohistochemistry in 69 specimens of human acoustic neuroma,and the correlation of TGF-β 1 with PCNA labeling index was analyzed.Results In solid and recurrence groups, the correlation of TGF-β 1 with PCNA was positive,and in cystic degenerative group,there was no correlation. The difference of TGF-β 1and PCNA was not significant among three groups which were classified by their size and there were no correlation in three groups either.Conclusions In solid and cystic tumor, TGF-β 1 was linked to cell proliferation, and could be taken as an important factor to evaluate the tumor progression and recurrence.

关 键 词：听神经瘤 转化生长因子Β1 增殖细胞核抗原 免疫组织化学 

分 类 号：R739.41[医药卫生—肿瘤]