7-ACA的吸收值对HR-756色级影响的探讨  

Discussion of Influence of Absorbance of 7-ACA to the Color of Cefotaxime(HR-756)

作　　者：尹丽红[1] 王晶[1] 

机构地区：[1]哈药集团制药总厂,150086

出　　处：《黑龙江医药》2005年第3期189-190,共2页Heilongjiang Medicine journal

摘　　要：目的:探讨7-ACA 的吸收值对 HR-756成品色级的影响。方法:用紫外分光光度计测定7-氨基头孢烷酸(7-ACA)的吸收值,对7-ACA 的重结晶处理。结果:7-ACA 吸收值的变化对 HR-756色级有较大的影响。结论:对7-ACA 的质量控制只有含量、水份是不够的,必须对其吸收值进行规定,而且7-ACA 贮存不当会使7-ACA 吸收值上长,对 HR-756的色级影响较大。Objective:The influence of absorbance of 7-ACA to the color of Cefotaxime(HR-756) was discussed Methods:The absorbance of 7-ACA was determined with UV spectrophotometer.Results:The change of absorbance of 7-ACA was an important factor that influence the color of HR-756.Conclusion:Only to control assay and water content is not enough to the quality control of 7-ACA.It is necessary to control its absorbance.In addition,when 7- ACA was stored incorrectly,its absorbance would increase,which would influence the color of HR-756 very much.

关 键 词：7-ACA 吸收值 HIR-756 色级 吸收值 工艺流程图 

分 类 号：R914[医药卫生—药物化学]