不同HIFU辐照模式损伤离体牛肝的研究  

COMPARISON OF ABLATIONS OF BOVINE LIVER TISSUE IN VITRO BY DIFFERENT HIFU EXPOSURE PATTERNS

作　　者：孔炜伟[1] 尹振宇[1] 刘宝瑞[1] 

机构地区：[1]南京大学医学院附属鼓楼医院肿瘤中心,江苏南京210008

出　　处：《实用临床医药杂志》2005年第5期17-20,共4页Journal of Clinical Medicine in Practice

基　　金：江苏省卫生厅重点资助项目(H200349)

摘　　要：目的比较不同HIFU辐照模式损伤离体牛肝的优劣,为临床应用提供依据。方法固定声功率及辐照深度,总辐照时间分别为1、3、5s,采用长时单次辐照与短时多次辐照2种模式损伤离体牛肝,从靶点温升、超声灰度及病理改变等几方面进行比较。结果与短时多次辐照模式相比,长时单次辐照后靶点温度较高,可见靶区超声灰度增强,大体及光镜下靶区组织呈凝固性坏死,与正常组织分界清晰。结论2种HIFU辐照模式均可造成靶区离体牛肝组织坏死,长时单次辐照模式的损伤效果较好,但临床治疗中这2种辐照模式的优劣有必要进一步探讨。Objective To compare the ablations of bovine liver tissue in vitro by different HIFU exposure patterns. Methods With the same acoustic power and exposure deep, long-time HIFU exposure and short-time fractional HIFU exposure were applied to ablate bovine liver tissue in vitro at total exposure time 1 s, 3 s and 5 s respectively. Results Compared with short-time fractional HIFU exposure, long-time exposure can achieve higher temperature rise, ultraphonic change and shape pathological margin. Conclusion Although all of the two HIFU exposure patterns can effectively ablate the targeted bovine liver tissue, long-time exposure is better. This may not be the rule in clinical application.

关 键 词：高强度聚焦超声 升温 

分 类 号：R734.54[医药卫生—肿瘤]