4-(3-吲哚基)-3-丁烯-2-酮苯甲酰腙Schiff碱过渡金属配合物的合成、表征及生物活性研究  

Synthesis, Characterization and Biological Activities of Transition Metal Complexes with Schiff Base Ligand 4-[Indol-3-yl]-but-3-en-2-one Benzoyl Hydrazone

作　　者：孙纲春[1] 曲建强[2] 王流芳[2] 陈耐生[1] 李燕[3] 陈晓光[3] 谢晶曦[3] 

机构地区：[1]福州大学功能材料研究所,福州350002 [2]兰州大学应用有机化学国家重点实验室,兰州730000 [3]中国医学科学院中国协和医科大学药物研究所,北京100050

出　　处：《无机化学学报》2005年第7期1069-1072,共4页Chinese Journal of Inorganic Chemistry

基　　金：国家自然科学基金资助项目(No.50272027)。

摘　　要：A Schiff base ligand 4-[indol-3-yl]-but-3-en-2-one benzoyl hydrazone (HL), and its four transition metal complexes (ML2,M=Cu(, Ni(, Zn( and Co() have been prepared and characterized by means of elemental analysis, EI-MS, molar conductivity, IR, UV-Vis and 1H NMR. The results showed that HL as a bidentate ligand coordinated with transition metal ions to form four-coordination complexes. The antibacterial activity was studied by using the filter scraps diffusion method, and the results indicated that the ligand and the complexes had a low bacteriostatic activity against S. Aureu, P. Aeruginosa and E. Coli. The low in vitro antitumor activity of the title complexes was also observed by using MTT method against KB, A2780, Bel7402 and HELF.A Schiff base ligand 4-[indol-3-yl]-but-3-en-2-one benzoyl hydrazone (HL), and its four transition metal complexes (ML2,M=Cu(II), N(II), Zn(II) and C(II)) have been prepared and characterized by means of elemental analysis, EI-MS, molar conductivity, IR, UV-Vis and H-1 NMR. The results showed that HL as a bidentate ligand coordinated with transition metal ions to form four-coordination complexes. The antibacterial activity was studied by using the filter scraps diffusion method, and the results indicated that the ligand and the complexes had a low bacteriostatic activity against S. Aureu, P. Aeruglnosa and E. Coli. The low in vitro antitumor activity of the title complexes was also observed by using MTT method against KB, A2780, Be17402 and HELF.

关 键 词：过渡金属配合物 SCHIFF碱 苯甲酰腙 活性研究 analysis metal 合成 丁烯 吲哚 生物 表征 UV-VIS filter and Cu(Ⅱ) Ni(Ⅱ) Zn(Ⅱ) Co(Ⅱ) the The with form was 酮 its ^1H MTT IR HL 

分 类 号：O641.4[理学—物理化学] O625.632[理学—化学]