海洛因依赖者血清丙二醛含量和总超氧化物歧化酶活力的初步观察  

A PRIMARY OBSERVATION OF SEROUS MDA AND SOD OF HEROIN ADDICTS

作　　者：姜翼[1] 王庆[1] 钟海波 唐星明[1] 杨介文[2] 

机构地区：[1]第一军医大学中西医结合研究所,广州510515 [2]广州军区广花医院,广州510450

出　　处：《中国药物依赖性通报》1994年第4期236-238,242,共4页

摘　　要：采用硫代巴比妥法和黄嘌呤氧化酶法分别测定了212倒海洛因依赖者和100例正常人血清丙二醛含量和总超氧化物歧化酶活力水平。结果:海洛因依赖者血清丙二醛含量与正常人无显著性差异,且与滥用海洛因年限、滥用量和病情无关;血清总超氧化物歧化酶活力明显低于正常人,滥用者0.5a内该酶活力应激性增高,0.5a后明显降低。作者认为,海洛因依赖者机体抗氧化能力明显降低。The content of malondialdehyde (MDA) and the activity of superoxide dismutase (SOD) in the serum of the heroin addicts and normal control persons were examined biochemically. The results showed that there was no difference between the content of MDA in the serum of the heroin addicts and that of the normal; the activity of total SOD in the serum of the heroin addicts was significantly lower than that of the normal (P<0. 01). Our results suggested that heroin may inhibit the ability to antioxide in the human bodies.

关 键 词：超氧化物歧化酶活力 海洛因依赖者 丙二醛含量 初步观察 黄嘌呤氧化酶法 机体抗氧化能力 硫代巴比妥 显著性差异 滥用海洛因 活力水平 正常人 人血清 应激性 滥用者 

分 类 号：R457.1[医药卫生—治疗学] R595.5[医药卫生—临床医学]