中国畲族HLA－DRB1基因多态性研究  

Studying on the polymorphisms of HLA-DRB1 genes in Chinese She nationality

作　　者：张文峰[1] 郭俊明[1] 张志新[1] 李伟[1] 

机构地区：[1]北京红十字血液中心

出　　处：《赣南医学院学报》1996年第2期85-87,共3页JOURNAL OF GANNAN MEDICAL UNIVERSITY

基　　金：国家自然科学基金

摘　　要：本文首次报道了中国畲族ＨＬＡ－ＤＲＢ１的基因分型。以ＰＣＲ／ＳＳＰ方法对中国畲族１０５个血样本进行了ＤＮＡ分型，结果与我国汉族（北方、沈阳、广东）、布依族、突尼斯人和法国高加索族的相关资料进行比较分析，显示中国畲族ＨＬＡ－ＤＲＢ１的等位基因数与以上民族的等位基因数有显著性差异，呈现多态性分布。The typing of HLA-DRB1 genes in Chineses She nationality was reported.With the methods of PCR/SSP,the HLA-DRB1 genes of 1O5 samples were typde,The results were compared with those of Han nationality(northern China,Shenyan,Guangdong),Buyi,Tunisian and French Caucasoid.It demonstrated that the genes of She nationality had marked difference from the others,which had high polymorphism.

关 键 词：HLA-DRB1基因 多态性研究 畲族 中国 DNA分型 显著性差异 多态性分布 基因分型 首次报道 SP方法 比较分析 等位基 血样本 R/S 布依族 高加索 突尼斯 因数 

分 类 号：R733.710.2[医药卫生—肿瘤] R392.12[医药卫生—临床医学]