慢性肝炎肝纤维化血清学指标与肝功酶的相关性及其意义  

The significance of and correlation between serum parameters of liverfibrosis and ALT,AST,GGT in chronic hepatitis

作　　者：谢秋里[1] 

机构地区：[1]广东省佛山市顺德区第一人民医院感染科,528300

出　　处：《河北医药》2005年第5期340-341,共2页Hebei Medical Journal

摘　　要：目的探讨慢性肝炎肝纤维化血清学指标与肝功酶[丙氨酸转氨酶(ALT)、门冬氨酸转氨酶(AST)、谷氨酰转肽酶(GGT)]的相关性。方法采血检测342例慢性肝炎患者的血清纤维化指标[Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(Ⅳ-C)、透明质酸(HA)、层粘蛋连白(LN)]及ALT、AST、GGT,并探讨它们之间的关系。结果血清PCⅢ、HA水平与ALT、AST、GGT值间均有相关性(r分别为0.314、0.311、0.275及0.203、0.342、0.302,P均小于0.001),Ⅳ-C、LN水平与肝功酶无相关性。结论血清PCⅢ、HA水平与ALT、AST、GGT值间均呈正相关,故据其值判定肝纤维化程度时,应考虑到炎症活动度的影响,Ⅳ-C、LN水平与上述肝功酶无相关性。Objective To investigate the relationship between serum parameters of liver fibrosis and alanine-aminotransferase (ALT),aspartate-aminotransferase (AST),gama-glutamyltransferase (GGT) in chronic hepatitis.Methods The serum fibrosis parameters including type Ⅲ procollagen PCⅢ,type Ⅳ collagen (Ⅳ-C),hyaluronate acid (HA),Laminin (LN)] and ALT,AST,GGT were measured in 342 patients with chronic hepatitis,in order to investigate the correlation among these parameters.Results The serum levels of PCⅢ,HA were closely correlated with the levels of ALT,AST and GGT ( r =0.314 0.311 0.275 and 0.203 0.342 0.302, P <0.01),however, the levels of Ⅳ-C and LN were not correlated with the levels of ALT,AST and GGT.Conclusion There is positive correlation between the serum levels of PCⅢ,HA and the levels of ALT,AST,GGT,therefore the influence of inflammation degree should be taken into consideration while diagnosing the liver fibrosis degree in accordance to the serum levels of PCⅢ and HA;there is no correlation between the serum levels of Ⅳ-C,LN and the levels of ALT,AST and GGT.

关 键 词：慢性肝炎 肝纤维化 血清学指标 丙氨酸转氨酶 门冬氨酸转氨酶 谷氨酰转肽酶 

分 类 号：R575.2[医药卫生—消化系统]