子宫内膜癌雌孕激素受体检测的临床意义  

Estrogen and progesterone rectptors in endometrial carcinoma

作　　者：郝树远[1] 党小雨[1] 刘蓉[1] 

机构地区：[1]西安市中心医院,陕西西安710003

出　　处：《现代医药卫生》2005年第11期1323-1324,共2页Journal of Modern Medicine & Health

摘　　要：目的:检测子宫内膜癌组织中雌激素受体(ER)、孕激素受体(PR)表达的阳性率并探讨其与预后的关系。方法:用免疫组化法对32例子宫内膜癌标本进行ER、PR的检测。结果:子宫内膜癌组织中ER、PR的阳性率分别为53.1%、50.0%。ER、PR的阳性表达率与癌组织的细胞分化程度有关,随着子宫内膜癌组织学分级的增高,ER、PR阳性率表达率逐渐降低,ER的表达还与肌层浸润深度有关。结论:ER、PR均反应了子宫内膜癌的生物学行为,其测定对预测临床预后、指导临床选择内分泌治疗具有重要意义。Objective:To assay the positive expression rate of estrogen receptor(ER)and progesterone(PR)in endometrial carcinoma,and study its relationship with prognosis.Methods:ER and PR of32cases of endometrial carcinoma were measured by immunohistochemical method.Results:The positive expression rates of ER and PRwere53.1%and50.0%separately in endometrial carcinoma.Positive expression rates of ER and PR were related to the differentiated degree of tumor.The positive expression rates of ER and PR decreased gradually along with the grading increase of tumor tissue(P<0.05).ER positive expressionwas related with the depth of myometrial tumor invasion.Conclusion:The levels of ER and PR are associated with the biologic behaviors of endometrial carcinoma,and assaying the levels of ER and PR is important in predicting prognosis and selecting clinical endocrinotherapy.

关 键 词：子宫内膜癌 激素受体检测 临床意义 细胞分化程度 肌层浸润深度 雌激素受体 孕激素受体 免疫组化法 阳性表达率 组织学分级 生物学行为 内分泌治疗 癌组织 阳性率 临床预后 重要意义 临床选择 ER PR 

分 类 号：R737.33[医药卫生—肿瘤] R711[医药卫生—临床医学]