原发性乳腺癌组织中nm23基因的表达及其意义  

Expression and Clinical Significance of nm23 Genes in Primary Breast Carcinomas

作　　者：黄俊辉[1] 海健[1] 李洋[1] 申正堂[1] 杨怀才[1] 唐利立[1] 胡铁辉[2] 

机构地区：[1]中南大学湘雅医院肿瘤科,湖南长沙410008 [2]中南大学

出　　处：《中国医师杂志》2005年第5期648-649,共2页Journal of Chinese Physician

基　　金：湖南省社会发展科技资助项目(OISSY2008)

摘　　要：目的探讨原发性乳腺癌组织中nm23基因的表达及其意义。方法采用免疫组织化学S-P法检测286例原发性乳腺癌nm23基因表达情况并与乳腺癌病理类型、患者年龄、临床分期及腋淋巴结转移之间的关系进行分析。结果nm23的阳性率为65.7%,与病人年龄、肿瘤病理类型无关;肿瘤临床分期越高,nm23的阳性率越低;腋淋巴结转移组的nm23阳性率明显低于腋淋巴结无转移组(P<0.05)。结论乳腺癌组织中nm23基因表达与乳腺癌临床分期、腋淋巴结转移呈负相关,提示nm23基因可作为预测原发性乳腺癌淋巴结转移和评估肿瘤临床预后的标记物。Objective To study expression and clinical significance of nm23 genes in primary breast carcinomas. Methods The expression of nm23 was detected by immunohistochemical S-P method in 286 cases of primary breast carcinomas. Results The positive rate of nm23 expression was 65.7%. There was not a significant correlation between the positive rate of nm23 and patients' age, tumor pathological types. There was a significant relation between the expression of nm23 and tumor clinical stage, axillary lymph node metastasis, and the positive rate of nm23 expression in the cases of clinical stage I without axilliary lymph node metastasis was significantly higher than that in the cases of clinical stage III with axilliary lymph node metastasis. Conclusion The expression of nm23 gene was negatively related with clinical stage and axilliary lymph node metastasis in breast carcinomas, which indicated that nm23 gene expression may serve as an index for predicting lymph node metastasis and the prognosis of breast carcinoma.

关 键 词：乳腺癌组织 其意义 表达及 免疫组织化学S-P法 NM23基因表达 原发性乳腺癌 腋淋巴结转移 临床分期 病理类型 阳性率 表达情况 患者年龄 病人年龄 临床预后 转移组 肿瘤 负相关 标记物 

分 类 号：R737.9[医药卫生—肿瘤] R-26[医药卫生—临床医学]