尿纤维蛋白降解产物(FDP)半定量测定在诊断膀胱癌中意义的临床研究  

A Significance of Inspecting u-FDP Concentration with Half Quantify in the Diagnose Bladder Carcinoma

作　　者：赖建平[1] 万旭辉[1] 陈善勤[1] 王鹏[1] 李兴斌[1] 付招伦[1] 

机构地区：[1]四川省宜宾市第一人民医院泌尿外科,四川宜宾644000

出　　处：《华西医学》2005年第2期266-267,共2页West China Medical Journal

摘　　要：目的:探讨尿中纤维蛋白降解产物在诊断膀胱癌中的意义,寻求对人群进行膀胱癌筛查的简易、有效的方法。方法:以乳胶凝集半定量测定法分别测定正常人、良性血尿患者、膀胱癌患者各50人尿中FDP浓度。结果:正常对照组中42例尿FDP<2μg/ml、8例2μg/ml;良性血尿组尿FDP浓度35例<2μg/ml、12为2μg/ml、3例4μg/ml;膀胱癌组:6例2μg/ml、11例4μg/ml、26例8μg/ml、7例16μg/ml。膀胱癌组与正常对照组和良性血尿组之间FDP浓度具有显著性差异。进行比较,(P值分别为<0.01、<0.05)。结论:检测尿FDP浓度是一种简单有效的检出膀胱癌的方法,可望用于健康人群普查以便于早期发现膀胱癌。Objective:To investigate the significance of insepecting u-FDP concentration with half quantify in the diagnose of bladder carcinoma and try to find an effective method to screen bladder carcinoma in normal peoples.Methods:The urine-FDP concentration was inspected in 50 cases healthy peoples,50 cases with benign hematuria and 50 cases with bladder carcinoma with half quantitative emulsion agglutinate reaction respectively.Results:The u-FDP concentration≤2ug/ml in all cases of healthy control group;35 cases<2ug/ml,12 cases 2ug/ml,3 cases 4ug/ml in benign hematuria group;6 cases 2ug/ml,11 cases 4 ug/ml,26 cases 8ug/ml,7 cases 16ug/ml bladder carcinoma group.And the difference of u-FDP concentration was significant between bladder carcinoma group and healthy conteol group、benign hematuria(P<0.001,P<0.05).Conclusions:Insepecting concentration was an effective method to find bladder carcinoma and may be used to screen bladder carcinoma in normal peoples so as to find these concinomas eaelier.

关 键 词：尿纤维蛋白降解产物 膀胱肿瘤 半定量 诊断 FDP 定性实验 

分 类 号：R737.14[医药卫生—肿瘤]