酿酒酵母锌簇转录因子Pdr1和Pdr3的研究进展  

Advances in the Study on Zinc Cluster Transcription Factors Pdr1 and Pdr3 in Saccharomyces cerevisiae

作　　者：王德俊[1] 徐铮[1] 曹永兵[1] 姜远英[1] 

机构地区：[1]第二军医大学药学院药理学教研室,上海市200433

出　　处：《医学分子生物学杂志》2005年第3期217-219,共3页Journal of Medical Molecular Biology

基　　金：国家自然科学基金(No.30300442)~~

摘　　要：Pdrl(pleiotropic drug-resistant 1)和Pdr3是酿酒酵母中锌簇转录因子,具有调控多种多药耐药转运蛋白的作用。它们主要以二聚体的形式与靶基因的PDREs(Pdrlp/Pdr3p response elements,PDREs)区域结合,对多药耐药靶基因进行调控,从而引起酿酒酵母对环己亚胺、寡霉素等药物的耐药现象。Pdr3的表达调控还受到线粒体基因组的影响。Pdr1 and Pdr3 are zinc cluster transcription factors in Saccharomyces cerevisiae. They bind with PDREs of the target genes as homodimers or heterodimers, and in the presence of the activation domains they can regulate several transporter proteins correlated with pleiotropic drug resistance. In addition, mitochondrion genome in yeast can regulate the expression of Pdr3.

关 键 词：锌簇转录因子 Pdr1 Pdr3 酿酒酵母 

分 类 号：Q933[生物学—微生物学]