屏氧酶1与ATP结合盒转运子A1基因多态性的相互作用对血脂的影响(英文)  

Effect of the interaction between paranoxonase 1 and ATP-binding cassette transporter 1 gene polymorphism on serum lipid level

作　　者：肖志杰[1] 赵水平[2] 聂赛[2] 谭利民[1] 吴军[1] 蒋波[1] 卢伟[1] 

机构地区：[1]中南大学湘雅二医院神经内科,长沙410011 [2]中南大学湘雅二医院心内科,长沙410011

出　　处：《中华医学遗传学杂志》2005年第3期272-276,共5页Chinese Journal of Medical Genetics

摘　　要：目的探讨屏氧酶1(paranoxonase1,PON1)基因多态性与ATP结合盒转运子A1基因(ATPbindingcassettetransporter1,ABCA1)多态性对血脂水平的相互作用。方法1019例受试者,其中680例脑卒中患者及339名正常对照组人群。采用聚合酶链反应限制性片段长度多态性方法测定PON1A/B192和ABCA1R219K基因多态性。结果PON1A/B192各基因型之间血脂水平差异无统计学意义(P>0.05)。在ABCA1的RR、RK和KK3种基因型中,HDLC水平依次明显上升(P<0.05);TG水平依次呈下降趋势,相互之间差异无统计学意义。PON1基因型影响ABCA1基因型与血脂的关系,AA型/RR型和BB型/KK型的HDLC[(1.41±0.40)mmol/L,(1.41±0.39)mmol/L]高于BB型/RR型[(1.28±0.36)mmol/L],差异有统计学意义(P<0.05)。结论PON1基因型与ABCA1基因型的相互作用影响血脂水平。Objective To investigate the effect of interaction between paranoxonase 1 (PON1) gene polymorphism and ATP-binding cassette transporter 1 (ABCA1) genetic variation on serum lipid level. Methods Polymerase chain reaction-restricted fragments length polymorphism was used to determine PON1 A/B192 and ABCA1R219K genotype of 1019 subjects, including 680 patients with strokes and 339 healthy individuals as controls. Results No significant association between A/B192 genotype and any of the lipid measurements was detected. The levels of HDL-C in the subjects with RR, RK and KK genotypes showed a significant upward tendency respectively(P<0.5); the levels of their triglyceride (TG) tended downward respectively, but there were no significant differences between them. The relationship between R219K genotype and serum lipid level was modified by A/B192 genotype. The levels of HDL-C in the subjects with AA/RR genotype and BB/KK genotype [(1.41±0.40)mmol/L,(1.41±0.39)mmol/L] were significantly different from that in the subjects with BB/RR genotype[(1.28±0.36)mmol/L] (P<0.05). Conclusion The result exhibited an interaction of PON1 A/B192 and ABCA1 R219K on serum lipid level.

关 键 词：屏氧酶1 ATP 盒转运子A1 基因多态性 血脂 基因型 聚合酶链反应 

分 类 号：R743.3[医药卫生—神经病学与精神病学]