载脂蛋白A5基因-1131T>C多态性与冠心病易感性的关联研究(英文)  

Association between apolipoprotein A5 -1131 T>C p olymorphism and susceptibility of coronary artery disease in Chinese

作　　者：汤轶波[1] 孙屏[1] 郭冬平[1] 李晓宇[1] 陈琪[1] 范乐明[1] 

机构地区：[1]南京医科大学动脉粥样硬化研究中心,南京210029

出　　处：《中华医学遗传学杂志》2005年第3期281-283,共3页Chinese Journal of Medical Genetics

基　　金：江苏省卫生厅计划资助项目(H200218)~~

摘　　要：目的探讨载脂蛋白A5(apoA5)-1131T>C单核苷酸多态性与冠心病(CAD)发病风险之间的关系。方法经冠状动脉造影确诊的江苏地区冠心病患者235例,同一地区正常对照262名,采用PCRRFLP分析对apoA5基因的-1131T>C多态进行检测,比较不同基因型与个体血脂水平和冠心病患病风险的关系。结果-1131T>C单核苷酸多态位点等位基因T、C频率在CAD组和正常对照组中分别为59.57%、40.43%和65.65%、34.35%。CAD组中C等位基因的频率高于对照组(P<0.05)。与-1131TT基因型者比较,CC基因型者的冠心病患病风险显著增加(OR=1.872,95%CI=1.039-3.376,P=0.037),用Logistic回归模型对个体的年龄、性别、体重指数和抽烟、高血压等因素后,其患病风险仍明显增加(OR=2.285,95%CI=1.222-4.274)。对照组中不同基因型个体血浆甘油三酯水平差异有统计学意义(P=0.007),携带C等位基因的个体TG水平显著高于TT基因型个体。结论apoA5基因-1131T>C多态性C等位基因是中国人群中冠心病发病的危险因素之一,且与血浆TG水平的变化密切相关。Objective To investigate the relationship be tw een apolipoprotein A5 (apoA5)-1131T>C polymorphism and the susc eptibility of coronary artery disease (CAD) in Chinese. Methods The restriction fragment length polymorphism of apoA5 gene -1131T>C was studied using PCR in a case-control study which enrolled 235 patients with CAD diagnosed by angiography and 262 healthy controls from Jiangs u province. Results The frequencies of T, C allele were 59.57% ,40.43% and 65.65%, 34.35% in CAD group and control group respectively. There w as statistically significant difference in allele frequencies between CAD group and control group (P<0.05). The susceptibility to CAD for the CC genotype wa s much higher than that for wild type TT (OR=1.872,95%CI=1.039-3376, P =0037), even after the use of Logistic regression models (OR=2.285, 95%C I=1.222-4.274, P=0.012). In c ontrol group, there was significant difference in TG levels among different geno types, the C allele carriers had higher serum TG concentration(P=0.007). Conclusion apoA5 -1131T>C polymorphism is asso ciated with an increased risk of CAD and is also in strong association with serum TG levels.

关 键 词：载脂蛋白A5-1131T〉C 基因多态性 冠心病 易感性 甘油三酯 等位基因 

分 类 号：R541.4[医药卫生—心血管疾病] R394[医药卫生—内科学]