同步放化疗治疗中晚期宫颈癌的近期疗效观察  

The early efficacy of the concomitant chemoradiotherapy to the advanced cervical cancer.

作　　者：董灵[1] 宋怡兵[1] 李向东[1] 赵全德[1] 宋小奇[1] 

机构地区：[1]四川省阆中市人民医院肿瘤科,四川阆中637400

出　　处：《现代肿瘤医学》2005年第3期378-379,共2页Journal of Modern Oncology

摘　　要：目的观察同步放化疗对中晚期宫颈癌的近期疗效。方法将40例中晚期(Ⅱb～Ⅳa期)宫颈癌患者随机分为两组,单独放疗组(RT)20例,FP方案化疗联合放疗组(RT+C)20例。两组放疗方法相同,RT+C组在放疗开始、中、后分别给予FP方案化疗一周期DDP20mg/m2静滴,每日一次,连用5天,5-Fu300mg/m2静滴,每日一次,连用5天,同时给予适当水化及止吐药物。比较两组病例近期疗效及毒副反应。结果近期临床疗效:RT+C组CR12例(60.0%),PR8例(40.0%),有效率(CR+PR)100%;RT组CR7例(35.5%),PR5例(25.0%),SD8例(40.0%)。有效率(CR+PR)60.0%。RT+C组的CR及有效率均高于RT组。差异有显著性。结论同步放化疗可提高中晚期宫颈癌的近期疗效,毒性反应有所增加,但可以耐受。Objective To investigate the early outcome of the concomitant chemoradiotherapy to the advanced cervical cancer. Methods Forty cases with cervical cancer( FIGO Ⅱ_b to Ⅳ_a)were divided randomly into two groups:radiotherapy alone(20 cases)and radiation plus chemotherapy(FP)group.There was no difference of radiotherapy between the two groups.The RT+C cases who accepted FP regimen before the radiation,both during the period and after.And DDP ,once daily injection of vain, according to 20mg/m^2 and 5-Fu once daily iv.according to 300mg/m^2.These regimen were given for 5 days.And some medicine for vomiting was given to the RT+C cases.The efficacy and adverse effects of both goups were compared. Results The early outcome :the complete remission rate was 60% and partial remission was 40% in RT +C,the complete remission rate was 35% and partial remission was 25% in RT. The total response rate and complete remission of RT+C group was higher than that of the RT group. There was significant difference between the two groups.Conclusion The concomitant chemoradiotherapy can improve the early outcome of the advanced cervical cancer,and the adverse effects was raised,but that can be endured.

关 键 词：宫颈肿瘤 放射治疗 化学治疗 

分 类 号：R737.33[医药卫生—肿瘤]