咬合支持丧失后大鼠海马区神经组织形态学变化的透射电镜观察  

Morphological alterations of the nervous tissues in hippocampus of rats with loss of occlusion support: observed by transmission electron microscopy

作　　者：江青松[1] 姜婷[2] 冯海兰[2] 吴敏节[2] 丛伟红[3] 石川达也[4] 

机构地区：[1]首都医科大学附属北京安贞医院口腔科,主治医师北京100029 [2]北京大学口腔医学院修复科,教授北京100081 [3]中国中医研究院西苑医院,副研究员北京100091 [4]东京齿科大学

出　　处：《中华老年口腔医学杂志》2005年第2期104-106,共3页Chinese Journal of Geriatric Dentistry

摘　　要：目的:研究咬合支持丧失对高龄大鼠神经组织形态学方面的影响,从而探讨咬合支持对维持生理功能的重要性。方法:24只10月龄Wistar大鼠随机分为对照组、单侧磨牙拔除组和双侧磨牙拔除组,6周后,大鼠快速断头处死,透射电镜观察大鼠海马区神经组织形态。结果:与对照组相比,拔牙组大鼠海马区神经细胞核溶解、细胞膜完整性破坏和一些重要的蛋白合成细胞器消亡,以及突触数量减少,其中以双侧磨牙拔除组变化更为明显。结论:咬合支持丧失后6周,大鼠海马区神经组织形态学发生退行性变。Objective:To investigate the effects of loss of occlusion support on the morphology of nervous tissues, and discuss the importance of occlusion support in maintaining the physiologic health of aged animal. Methods:24 Wistar rats (10 months old) were randomly divided into three groups: unilateral group (molars in left side extracted), bilateral group (molars on both sides extracted), and control group (sham surgery). Six weeks later, all animals were decapitated and thehippocampus was dissected. The morphology of nervous tissues were observed by transmission electron microscopy(TEM). Results:TEM showed cell nucleus lysis, plasma membrane disintegration, disappearance of certain important organelles of protein synthesis, and synapse number decrease in rat hippocampus neurons after molar extraction. These changes were more significant in the bilateral group. Conclusion:This study suggested that loss of occlusion support may lead to degeneration of nervous tissues in hippocampus of rats.

关 键 词：透射电子显微镜检查 神经组织 海马 大鼠 咬合支持丧失 

分 类 号：R780.2[医药卫生—口腔医学]