51例非小细胞肺癌神经内分泌分化的研究  

A STUDY ON NON-SMALL CELL LUNG CARCIRMAS WITH NEUROENDOCRINE DIFFERENTIATION OF 51 CASES

作　　者：蒋世旭 王祖乾[1] 邬关德[1] 吕廉捷[1] 谢永康[1] 胡礼振[2] 杨燕玲[2] 

机构地区：[1]泸州医学院病理学教研室,646000 [2]泸州医学院电镜室,646000

出　　处：《泸州医学院学报》1994年第3期164-167,共4页Journal of Luzhou Medical College

摘　　要：应用光镜、电镜及免疫组化方法对51例非小细胞肺癌的神经内分泌分化特征进行研究．结果表明，51例NSCLC中有27例具有神经内分泌分化特征，占总病例的52．94％。其中电镜发现有神经内分泌颗粒者13例（25．49％），神经内分泌特异性免疫级化标记（NSE和／或Leu-7）阳性16例（31．4％）。组织学类型主要是腺癌。本文还对具有神经内分泌分化特征的非小细胞肺癌的治疗和预后以及肺癌的起源和分类进行了探讨。Neuroendocrine differentiation features of Non-small cell Lung carcinoma (NSCLC) of 51 cases were studies by a light microscopic. Ultrastructural and immuno-histochemical method, Our results suggest that 27 of 51 cases NSCLC had neuroendocrine sifferentiation features (52. 94% of a total cases ), of 51 cases, Neuroendocrine granules of 13 cases were poritive by electron microscpy (25.49% ) and neuroendocrine special immunohistochemical marker (NSE and/or Leu - 7 ) of 16 .Cases were positive (31. 4% ), Histologic type of them were mainly adnocarcimoma. Besides, Trement,progrosis, histologic origin and classification of NSCLC with neuroendocrine diffrentiation were dis-cussed.

关 键 词：肺肿瘤 非小细胞肺癌 神经内分泌 分化 

分 类 号：R734.202[医药卫生—肿瘤]