乙型肝炎患者血清sTRAIL水平与肝损伤的相关性研究  

The role of sTRAIL in the pathogenesis of HBV infection in human being

作　　者：岳凤娥[1] 刘典勇[2] 宋静[2] 张利宁[2] 

机构地区：[1]济南市传染病医院,山东济南250021 [2]山东大学医学院

出　　处：《山东医药》2005年第14期13-14,共2页Shandong Medical Journal

摘　　要：目的探讨可溶性肿瘤细胞坏死因子相关凋亡诱导配体(sTRAIL)在乙型肝炎(下称乙肝)发病机制中的作用。方法采用ELISA法检测了112例乙肝患者血清sTRAIL水平,将其与肝功能相关指标进行相关性分析。结果乙肝患者发病期血清sTRAIL水平显著高于正常对照组;恢复期血清sTRAIL水平接近正常;急、慢性乙肝患者血清sTRAIL水平与丙氨酸氨基转移酶(ALT)、门冬氨酸氨基转移酶(AST)和血清总胆红素(TBIL)均呈显著负相关,与血清白蛋白(ALB)水平呈显著正相关。结论sTRAIL诱导细胞凋亡是肝细胞损伤的机制之一。Objective To explore the role of sTRAIL (soluble TRAIL) in the pathogenesis of HBV infection in human being.Methods sTRAIL in 112 patients' sera was examined with ELISA.Correlationship between sTRAIL and liver functional parameters were analysed.Results The level of sTRAIL in patients with various clinical types of hepatitis B were all higher than that in normal persons and almost normal in recovering stage cases.sTRAIL level in acute and chronic hepatitis B,was negatively correlated with ALT,AST and TBIL,and positively correlated with serum albumin.Conclusion High level of sTRAIL is related to liver damage and apoptosis induced by sTRAIL is one of the mechanisms for liver damage in HBV infection. [

关 键 词：STRAIL 乙型肝炎患者 相关性研究 水平 丙氨酸氨基转移酶(ALT) 肝损伤 门冬氨酸氨基转移酶 相关凋亡诱导配体 肿瘤细胞坏死因子 ELISA法检测 慢性乙肝患者 血清总胆红素 诱导细胞凋亡 相关性分析 正常对照组 血清白蛋白 

分 类 号：R730.21[医药卫生—肿瘤] R512.62[医药卫生—临床医学]