P^(16)、Rb和P^(53)在喉鳞癌组织中的表达及意义  

Expression and clinical signifcance of P^(16),Rb and P^(53) in the laryngeal squamous cell carcinoma

作　　者：桑建中[1] 娄卫华[1] 

机构地区：[1]郑州大学第一附属医院,河南郑州450052

出　　处：《山东医药》2005年第14期17-19,共3页Shandong Medical Journal

摘　　要：目的探讨抑癌基因P16、Rb和P53蛋白表达与喉鳞癌发生的关系及三者的相关性。方法采用免疫组化(SABC)方法检测80例喉鳞癌患者癌组织及癌旁组织(30例),30例声带息肉患者手术标本中抑癌基因P16、Rb和P53的表达情况。结果声带息肉、癌旁组织及癌组织P53表达率分别为6.66%、46.6%和66.2%(P<0.0001);P16表达率分别为86.6%、63.3%和41.2%(P<0.0001);Rb表达率分别为80.3%、66.6%和52.5%(P<0.05)。P53蛋白表达与临床分期、癌细胞分化程度和淋巴结转移有关(P<0.05)。癌组织中P16和Rb蛋白的表达呈负相关(P<0.05)。P16和Rb的表达与临床分期、细胞分化程度和淋巴结转移无关。结论P16、Rb和P53的异常表达与喉鳞癌的发生与进展有关;P53可作为判定喉鳞癌患者预后的一个指标。Objective To investigate the relation of P^16 ,Rb and P^53 with carcinogenesis of laryngeal squamous cell carcinoma (LSCC) and correlation ship among them.Methods The expression of P^16 ,Rb and P^53 were examined by immunohistochemistry method in 80 cases of LSCC,30 cases of paracancerous tissues and 30 cases polyp of vocal cord.Results In polyp of vocal cord,paracancerous and carcinoma,the positive rates of P^53 were 6.66%,46.6% and ~66.2% (P<0.0001);P^16 were 86.6%,63.3% and 41.2%(P<0.0001);Rb were 80.3%,~66.6% and 52.5%(P<0.05)respectively.There were significant correlationship between the expression of P^53 and clinic stage,cell differentiation and lymph node metastasses(P<0.05).Conclusions The abnormal expression of P^16 ,Rb and P^53 were related to the carcinogenesis and development of laryngeal carcinoma.P^(53) is an index to estimate the prognosis of LSCC.

关 键 词：P^53 鳞癌组织 抑癌基因P^16 表达及 癌细胞分化程度 淋巴结转移 蛋白表达 癌旁组织 声带息肉 临床分期 表达率 免疫组化 手术标本 表达情况 RB蛋白 P^16 异常表达 P^53 癌患者 相关性 癌发生 负相关 p16 喉鳞癌 

分 类 号：R735.34[医药卫生—肿瘤] R739.8[医药卫生—临床医学]