肺癌组织内血管密度的X线解剖学研究及其临床意义  

X-anatomy Study and Computer Image Analysis of Distribution of Microvessel Density in Pulmonary Carcinoma

作　　者：高从敬 陈尔瑜[2] 蔡国君[2] 

机构地区：[1]解放军第97中心医院放射科,江苏徐州221004 [2]第二军医大学解剖学教研室

出　　处：《解剖与临床》2005年第2期98-100,共3页Anatomy and Clinics

摘　　要：目的:定性和定量研究肺癌组织内肿瘤微血管密度。方法:对100例肺癌支气管动脉造影资料进行分析,并利用计算机图像处理系统进行肿瘤组织内支气管动脉的分支血管密度相对分布面积和相对平均灰度进行研究。结果:肺癌表现为血管结构异常和肿瘤血管染色;本组测得肿瘤微血管密度(MVD)中位值为60,MVD≥60%为多血供(N=19)、MVD为30%～60%为中血供(N=63)、MVD≤30%为少血供(N=18)。肺癌组织内血管密度的X线解剖学资料有10种征像。结论:肺癌组织内血管密度值代表肺癌组织的供血范围局限,应考虑其它动脉参与肿瘤供血和介入治疗。Objective:To study the distribution of the microvessel density in pulmonary carcinoma qualitatively and quantitatively.Methods:The bronchoarteriography of 100 cases of pulmonary carcinoma tissue was observed and analyzed.The processing system and the comparative distributing area and comparative average grey degree were calculated by computer image analysis.Results:In the pulmonary carcinoma,the microvessel density was abnormal in structure and the arteries were stained.In the rich blood supply group the area of stained arteries/area of carcinoma(Aa%) was over 60%(19 cases).In the common blood supply group,the Aa% was between 30～60%(63 cases).Int the poor blood supply group,the Aa% was below 30%(18 cases).The types of X-ray expression of the mirovessel density were present in pulmonary cacinoma and might be useful for clinical diagnosis.Conclusion:The blood supply area of the microvessel density in primary carcinoma is limited,so other arteries should be considered for blood supplying and introduced therapy.

关 键 词：组织内 解剖学研究 临床意义 微血管密度(MVD) 计算机图像处理系统 肿瘤微血管密度 支气管动脉造影 血管结构异常 X线解剖学 定量研究 肿瘤血管 肺癌组织 介人治疗 肿瘤供血 血供 密度值 

分 类 号：R734.2[医药卫生—肿瘤]