苦瓜粗多糖提取物降血糖作用的实验研究  

The hypoglycemic effects of crude polysaccharides extract from Momordica charantia in mice

作　　者：郑子新[1] 滕俊英[1] 刘剑英[2] 邱继红[1] 欧阳红[1] 薛长勇 

机构地区：[1]中国人民解放军总医院营养科,北京100853 [2]济南军区青岛第一疗养院

出　　处：《卫生研究》2005年第3期361-363,共3页Journal of Hygiene Research

基　　金：解放军总医院学科带头人工程基金项目

摘　　要：目的　研究苦瓜粗多糖提取物(CPS)对正常及糖尿病小鼠血糖调节作用。方法　采用2 4只正常小鼠进行口服葡萄糖耐量试验,一次性经口给予动物葡萄糖3g kgbw ,实验组同时一次性给予CPS 1g kgbw ,对照组给予等量的生理盐水;应用1型和2型糖尿病模型小鼠,分别在随机进食和空腹情况下一次性经口给予CPS(1g kgbw) ,测定给药后2h、4h血糖水平,并与对照组血糖进行比较。结果　葡萄糖耐量试验中,实验组小鼠给予CPS 0 . 5h、1h后血糖水平显著低于对照组(分别低于对照组16 4 %和16 . 5 % ) ,差别具有显著性意义(P <0 .0 5和P <0 . 0 1)。2种糖尿病模型动物服用CPS后,各时点血糖水平较对照组显著下降(P <0 . 0 5 )。结论　苦瓜多糖粗提物对正常小鼠糖耐量有改善作用,能显著降低糖尿病模型动物随机及空腹血糖。Objective In order to study the hypoglycemic effects of crude polysaccharides extract from momordica charantia in normal and diabetic mice. Methods Oral glucose tolerance test was carried out in 24 normal mice, CPS was orally administered in experiment group at 1g/kg BW. 80 diabetic mice (type 1 and type 2 diabetic model) were divided into two groups randomly, CPS was administered at ad lib and fasted condition in experiment group at 1g/kg BW, blood glucose was measured at different time. Results In normal mice, after administered glucose(3g/kgBW) the blood glucose level of experiment group at 0.5,1h was significantly lower than that of control group(16.4% and 16.5% lower than control group respectively, P<0.05 and P<0.01). In diabetic mice, the fasted and ad lib blood glucose after administering CPS orally 2h,4h were lower than that of control group(P<0.05 and P<0.01 respectively).Conclusion CPS can improve OGTT in normal mice, and has significant hypoglycemic effect in two types diabetic mice.

关 键 词：苦瓜 多糖提取物 降血糖 糖尿病 

分 类 号：R977.15[医药卫生—药品] R587.1[医药卫生—药学]