胃、结肠癌的癌组织周边区淋巴管的形态学特征(英文)  

Morphologic Features of Lymphatic in Periphery Region of Gastric Carcinoma and Colon Carcinoma

作　　者：刘慧冬[1] 赵玲辉[1] 张雅芳[1] 李玉兰[1] 李晓冬[1] 杨树才[1] 李益民[1] 聂春生[1] 

机构地区：[1]哈尔滨医科大学解剖学教研室,黑龙江哈尔滨150086

出　　处：《癌症》2005年第6期699-703,共5页Chinese Journal of Cancer

基　　金：国家自然科学基金(No.30270697);黑龙江省自然科学基金(No.D01-07)~~

摘　　要：背景与目的:关于淋巴转移机制,大多数研究局限于淋巴管的分布。本研究的目的是观察在癌组织周边区的淋巴管形态、分布和淋巴管内皮细胞的变化。方法:取人胃癌、大肠癌手术标本各10例,制作大鼠结肠癌模型20例。在光镜下观察淋巴管形态及其内皮细胞的超微结构。使用图像分析仪,测量癌组织周边区和正常区淋巴管的数密度和体密度,计算淋巴管开放率和破坏率。结果:癌周边区的淋巴管管腔扩张、管壁被破坏;淋巴管内皮细胞被溶解破坏,遗留断裂的碎片,细胞器出现病理变化。癌周边区淋巴管的密度高于正常区。人结肠癌癌周边区和正常区的淋巴管数密度分别为(10.2±1.7)/mm2和(5.1±0.8)/mm2(P<0.05),体密度分别为(1.5±0.2)%和(0.7±0.0)%(P<0.05)。人胃癌癌周边区和正常区的淋巴管数密度分别为(8.0±0.9)/m m 2和(3.4±0.6)/m m 2 (P <0.01),体密度分别为(1.6±0.3)%和(0.8±0.2)%(P <0.05)。鼠结肠癌模型、人胃癌和结肠癌的癌周边区淋巴管开放率(22.2%、35.0%、25.8%)明显高于正常区(7.8%、8.0%、5.0%)(P <0.05)。鼠结肠癌模型和人胃癌的癌周边区淋巴管破坏率(20.1%和35.3%)也明显高于正常区(0和2.0%)(P <0.05)。结论:与正常组织比较,癌组织周边区淋巴管管腔扩张,管壁破坏,内皮细胞被溶解破坏,淋巴管密度增大。BACKGROUND & OBJECTIVE: Most of the studies on lymphatic metastasis mechanism of carcinoma are confined to distribution of lymphatics. This research was to observe distribution and morphologic features of the lymphatics in periphery region of carcinoma, and morphologic changes of lymphatic endothelia. METHODS: Specimens were obtained from 10 patients with gastric carcinoma and 10 patients with colon carcinoma; 20 mice models bearing colon carcinoma were established. Morphology of lymphatics and ultrastructure of lymphatic endothelia were observed under microscope. Number density and volume density of lymphatics in periphery region of carcinoma and normal region were measured using computer image analysis system; open rate and destructive rate of lymphatics were calculated. RESULTS: The lymphatics in periphery region of carcinoma were dilated; their walls were disintegrated. Lymphatic endothelia were dissolved and destroyed into broken fragments; the organellae showed pathologic changes. Number density and volume density of lymphatics were significantly higher in periphery region of colon carcinoma than in normal region [(10.2±1.7)/mm2 vs. (5.1±0.8)/mm2, P < 0.05; (1.5±0.2)% vs. (0.7±0.0)%, P < 0.05], and were significantly higher in periphery region of gastric carcinoma than in normal region [(8.0±0.9)/mm2 vs. (3.4±0.6)/mm2, P < 0.01; (1.6±0.3)% vs. (0.8±0.2)%, P < 0.05]. Open rate of lymphatics was significantly higher in periphery regions of mice model colon carcinoma, human gastric carcinoma, and colon carcinoma than in relevant normal regions (22.2% vs. 7.8%, 35.0% vs. 8.0%, and 25.8% vs. 5.0%, P < 0.05). Destructive rate of lymphatics was significantly higher in periphery regions of mice model colon carcinoma, and human gastric carcinoma than in relevant normal regions (20.1% vs. 0, and 35.3% vs. 2.0%, P < 0.05). CONCLUSION: Compare with the lymphatics in normal tissue, the lymphatics in periphery region of carcinoma tissue are dilated with disintegrated walls;the lymphatic endothelia are destroyed;t

关 键 词：癌组织 淋巴管 内皮细胞 超微结构 

分 类 号：R735[医药卫生—肿瘤]