血浆MMPs水平与甲状腺乳头状癌浸润转移的关系  

Correlations of Serous Levels of Matrix Metalloproteinases (MMP-2 and MMP-9) to Invasion and Metastasis of Papillary Thyroid Carcinoma

作　　者：于华众[1] 李章平[2] 李上共[3] 吴朝明[1] 

机构地区：[1]温州医学院附属第二医院内分泌科,浙江温州523000 [2]温州医学院附属第一医院急诊科,浙江温州523000 [3]温州医学院附属第一医院心内科,浙江温州523000

出　　处：《癌症》2005年第6期740-742,共3页Chinese Journal of Cancer

摘　　要：背景与目的:甲状腺乳头状癌是常见的甲状腺恶性肿瘤,目前尚无理想的血液学指标来反映其生物学特性,本研究观察血浆基质金属蛋白酶(MMP)-2、-9活性与甲状腺乳头状癌侵袭和转移的关系。方法:温州医学院附属第二医院1999～2003年共有经病理确诊、行甲状腺癌改良根治术的甲状腺乳头状癌患者74例,用明胶酶谱法测定患者血浆MMP-2和MMP-9活性。结果:淋巴结转移组的血浆活化MMP-2和MMP-9水平(71.9±11.7、15.5±6.1)明显高于无淋巴结转移组(35.2±6.6、7.3±2.3)(P<0.001);包膜及包膜外浸润组的血浆活化MMP-2和MMP-9水平(70.5±13.0、14.7±6.1)明显高于包膜内浸润组(35.4±7.9、8.0±4.2)(P<0.001);而肿瘤直径≥1cm组和<1cm组血浆活化MMP-2和MMP-9水平(55.4±20.4vs.59.3±20.8,10.8±5.7vs.13.7±6.8)无显著性差异(P>0.05),各组之间血浆总MMP-2和MMP-9水平无显著性差异(P>0.05)。结论:明胶酶的活化形式MMP-2和MMP-9的血浆水平与甲状腺乳头状癌的转移、侵袭有关,与肿瘤的大小无关。BACKGROUND & OBJECTIVE: Papillary thyroid carcinoma is a common carcinoma in thyroid without ideal hematological biomarkers to indicate its biological feature. This study was to explore the correlation of serous levels of matrix metalloproteinases (MMP-2 and MMP-9) to invasion and metastasis of papillary thyroid carcinoma. METHODS: Serous levels of MMP-2 and MMP-9 of 74 patients with pathologically confirmed papillary thyroid carcinoma were measured by zymography. All patients were treated with modified radical operation in the Second Affiliated Hospital of Wenzhou Medical College from 1999 to 2003. RESULTS: Serous levels of activated MMP-2 and MMP-9 were significantly higher in patients with lymph node metastases than in patients without lymph node metastases (71.9±11.7 vs. 35.2±6.6, P < 0.001; 15.5±6.1 vs. 7.3±2.3, P < 0.001), and were significantly higher in patients with carcinoma invaded in and through integument than in patients with carcinoma invaded within integument (70.5±13.0 vs. 35.4±7.9, P < 0.001; 14.7±6.1 vs. 8.0±4.2, P < 0.001). There was no significant difference in serous levels of activated MMP-2 and MMP-9 between patients with carcinoma diameter of ≥1 cm and < 1 cm (55.4±20.4 vs. 59.3±20.8, 10.8±5.7 vs. 13.7±6.8). There was also no significant difference in serous levels of total MMP-2 and MMP-9 between every 2 groups mentioned above (P > 0.05). CONCLUSION: Serous levels of activated MMP-2 and MMP-9 relate with invasion and metastasis of papillary thyroid carcinoma, but not relate with tumor size.

关 键 词：甲状腺肿瘤 基质金属蛋白酶 肿瘤转移 

分 类 号：R736.1[医药卫生—肿瘤]