对氨基-β-苯乙醇的制备研究  

Study on Preparation of 4-Amino-β-phenethanol

作　　者：李树安[1] 

机构地区：[1]淮海工学院化学工程系,江苏连云港222005

出　　处：《化工时刊》2005年第5期15-17,共3页Chemical Industry Times

基　　金：江苏省教育厅自然科学基金资助项目 (0 4KJD1 50 0 1 7)

摘　　要：研究了苯乙醇用乙酸酯化、用混酸硝化、水解和催化氢化还原制备对氨基- β-苯乙醇的工艺。5 0g苯乙醇与3 0g乙酸、0 . 5mL浓硫酸和5 0g苯恒沸脱水酯化,用5 0g混酸(硝酸/浓硫酸=1∶1 )在- 5～0℃硝化4h ,用2 0 %NaOH水解,然后催化氢化还原并分离出对氨基- β-苯乙醇2 6 .7g ,总收率4 8 .2 % ,纯度98 . 4%。Amino-β-phenethanol was prepared by sequence steps of esterification of β-phenethanol and acetic acid,nitration with HNO 3 and H 2SO 4,alkaline hydrolys is and catalytic hydrogenation.Thus,50g β-phenethanol reacted 30g acetic acid and 0.5mL H 2SO 4,80mL benzene as azeotropic agent,then nitrated with 50g mixture of HNO 3 and H 2SO 4 at-5～0℃ for 4h,hydrolyzed with 20%NaOH,and underwent catalytic hydrogenation and isolated to obtain 26.7g 4-amino-β-phenethanol with total yield 48.2% and purity 98.4%.

关 键 词：Β-苯乙醇 对氨基 制备研究 混酸硝化 还原制备 催化氢化 NAOH 浓硫酸 总收率 酯化 乙酸 水解 硝酸 分离 

分 类 号：TQ243.4[化学工程—有机化工]