刺激性泻剂对大鼠结肠肌间神经丛超微结构的影响  

Effects of stimulant laxative on the ultrastructure of rat colonic myenteric nerve plexus

作　　者：王梅[1] 吕宾[2] 范一宏[2] 杨林[2] 许毅[2] 

机构地区：[1]温州市第二人民医院,浙江温州325000 [2]浙江省中医院,浙江杭州310006

出　　处：《基础医学与临床》2005年第5期434-436,共3页Basic and Clinical Medicine

基　　金：浙江省教委基金(2003387)

摘　　要：目的本实验主要研究刺激性泻剂对大鼠结肠肌间神经丛超微结构的影响及其在慢性便秘发生、发展过程中的作用机制。方法通过建立“泻剂结肠”的动物模型,应用电镜技术对正常大鼠及模型大鼠结肠肠壁肌间神经丛超微结构进行观察及对照研究。结果与正常对照组相比,“泻剂结肠”大鼠肠壁肌间神经丛超微结构有明显的病理损害,表现为结肠肌间神经丛可见神经元细胞线粒体轻度肿胀,神经纤维轴突内线粒体肿胀破裂,“嵴”状结构不完整,神经束轴突及树突扩张,电子密度不均匀,部分明显扩张形成空泡。结论长期应用刺激性泻剂可损害结肠肌间神经丛,其超微结构的改变可能是慢性便秘进一步发展和加重的病理基础之一。ObjectiveTo study the Effects of stimulant laxative on the ultrastructure of rats colonic myenteric nerve plexus,and the mechanisms about the occurrenc and development of chronic constipation. An animal model of cathartic colon was established by stimulant laxative. ResultsThe ultrastructure of the colonic myenteric nerve plexus were observed by electron microscopy. Compared with normal group, the ultrastructure of the rats colonic myenteric nerve plexus were impaired apparently. We see the mitochondry of the neur cells swell slightly, the mitochondry in the nerve fibers axis-cylinder swell and disrupted, and the structure of crest was dismtact, the nerve tract axis-cylinder and dendrite expanded, parts of them formed vacuoles. The long-term abuse of stimulant laxative can impaire the colonic myenteric nerve plexus, the structural damage may be one of pathogenetic factors of chronic constipation.

关 键 词：结肠肌间神经丛 刺激性泻剂 超微结构 “泻剂结肠” 慢性便秘 正常对照组 细胞线粒体 线粒体肿胀 作用机制 动物模型 对照研究 模型大鼠 正常大鼠 电镜技术 病理损害 神经纤维 电子密度 长期应用 病理基础 神经元 神经束 

分 类 号：R574.62[医药卫生—消化系统]