心理社会因素应激对免疫功能的影响  

Effect of the stress of psychosocial factors on immunological function

作　　者：陈爱国[1] 李万俊[1] 颜军[1] 

机构地区：[1]江苏扬州大学体育学院,江苏省扬州市225002

出　　处：《中国临床康复》2005年第16期134-135,共2页Chinese Journal of Clinical Rehabilitation

基　　金：江苏省教育厅自然科学研究指导性项目(IK0310064)~~

摘　　要：目的:探讨非损伤性应激中心理社会因素引起的机体免疫功能改变的过程以及细胞免疫的变化。资料来源:计算机检索www.ncbi.nlm.gov,www.elsevier.lib.tsinghua.edu.cn,www.cjfd.cnki.net,手工检索7种以上相关国外期刊,检索时间为1990-01/2004-12关于心理社会因素的应激对免疫功能影响的相关文献。资料选择:选择关于心理因素、社会因素对心理应激的影响,以及免疫功能,尤其是T细胞、B细胞和NK细胞等细胞免疫的文献,不排除其是否为随机、盲法等原始论著。资料提炼:检索到64篇相关文章,内容呈不同程度重复的有14篇,对其余50篇进行分类整理,其中21篇选用为参考文献。资料综合:实验研究及病例均证明了心理社会因素对免疫机体功能影响的广泛性和重要性;应激致机体免疫应答过程中,T细胞、B细胞和NK细胞3类淋巴细胞是发挥核心作用的最主要的免疫细胞。免疫细胞中T细胞是最重要的调节细胞,多数研究表明心理社会刺激抑制T细胞的活性,使B淋巴细胞成熟受阻,抗体生成数量减少,免疫反应延迟,NK细胞数量减少,白细胞介素1含量增加、活性升高,白细胞介素2的生成受到抑制等。结论:心理社会因素的应激引起机体免疫功能的改变,主要是通过T,B和NK等免疫细胞以及细胞因子的变化来实现的。OBJECTIVE: To investigate the process of the organic immunological functional changes caused by psychosocial factors in non injury stresses, and study the ch anges of cellular immunity. DATA SOURCES: An online search of www.ncbi.nlm.gov, www.elsevier.lib.tsinghua. edu.cn and www.cjfd.cnki.net was undertaken, and more than 7 relevant journals a t home and abroad were searched manually to identify the articles related to the influence of the stress of psychosocial factors on the cellular function publis hed between January 1990 and December 2004. STUDY SELECTION: Articles about the effects of pshycological and social factor s on psychological stress and immunological functions, especially about the cell ular immunity of T cells, B cells and NK cells, were selected. The original work s whether randomized and blinded study or not were not excluded. DATA EXTRACTION: Sixty four relevant studies were collected, including 14 wit h repetitive contents to different degree, and the rest 50 were classified and s orted, and 21 of them served as references. DATA SYNTHESIS: The experimental studies and cases proved the extension and im portance of the effect of psychosocial factors on immune function; During the pr ocess of stress induced response of organic immunity, T cells, B cells and NK ce lls were the most important 3 immunocytes that played core roles.Among the immun ocytes,T cells were the most important regulatory cells, most studies showed tha t psychosocial stress inhibited the activity of T cells, suppressed the prolifer ation of B lymphocytes, reduced the amount of antibody, delayed the immunologic reaction, decreased the amount of NK cells, increased the content of interleukin 1 and enhanced its activity, and inhibit the production of interleukin 2. CONCLUSION: The changes of organic immunological function can be caused by the stress of psychosocial factors, which is realized by the changes of T cells, B cells, NK cells and cytokine.

关 键 词：心理学 社会 免疫性 研究 

分 类 号：R742.1[医药卫生—神经病学与精神病学]