阿莫西林/β-环糊精包合作用研究  

Study on the inclusion complex of amoxicillin and β-cyclodextrin

作　　者：陆亚鹏[1] 任勇[1] 王亚娜[1] 杨星昊[1] 刘华红 徐彩萍 

机构地区：[1]南京师范大学 [2]南京臣功制药有限公司,江苏南京210038

出　　处：《中国药学杂志》2005年第10期757-759,共3页Chinese Pharmaceutical Journal

基　　金：国家自然科学基金资助项目(30371690)江苏高校高新技术产业发展项目(JH03-012)

摘　　要：目的研究阿莫西林/β-环糊精的包合,寻找改善阿莫西林制剂性能的方法。方法利用紫外光谱法和相溶解度法研究水溶液中阿莫西林/β-环糊精包合作用。采用研磨法制备阿莫西林/β-环糊精包合物,并用差示热分析和X射线衍射验证包合物的形成。比较了阿莫西林和包合物的体外溶出速率。结果阿莫西林和β-环糊精能够形成稳定的包合物。当体系中β-环糊精的浓度为6.16×10-3mol·L-1时,阿莫西林的溶解度提高2.89倍。包舍物在10min内的体外溶出速率上升7.2倍。结论环糊精包合技术显著提高了阿莫西林的溶解度和溶出度。OBJECTIVE: The inclusion complex of amoxicillin/β-cyclodextrin was investigated to improve the performance of the amoxicillin preparation. METHODS: In aqueous solution, the inclusion complex of amoxicillin/β-cyclodextrin was studied by Ultraviolet Spectroscopy and phase solubility. The inclusion complex was prepared by trituration and was confirmed by DTA and X-ray diffraction. The dissolution rates of amoxicillin and inclusion complex were compared. RESULTS: In aqueous solution, inclusion complex easily formed between amoxicillin and β-cyclodextrin. In the presence of 6.16 × 10 -3 mol &middot L-1 β-cyclodextrin, the solubility of inclusion complex was 3.89 times than that of amoxicillin. The dissolution rate in 10 minutes was 8.2 times as much as that of amoxicillin. CONCLUSION: The solubility and dissolution of amoxicillin were improved with β-cyclodextrin.

关 键 词：阿莫西林 Β-环糊精 包合常数 相溶解度法 

分 类 号：R943[医药卫生—药剂学]