奥沙利铂联合5-氟尿嘧啶和亚叶酸钙治疗晚期大肠癌  

Chemotherapy with Oxaliplatin Combined with 5-Fluorouracil and Folinic Acid in Patients with Advanced Colorectal Cancer

作　　者：钟陆行[1] 熊建萍[1] 张凌[1] 邱峰[1] 罗辉[1] 徐俊[1] 陶庆松[1] 

机构地区：[1]江西医学院第一附属医院癌症中心,江西南昌330006

出　　处：《实用临床医学（江西）》2005年第6期16-17,共2页Practical Clinical Medicine

摘　　要：目的:探讨奥沙利铂联合5氟尿嘧啶和亚叶酸钙方案在晚期大肠癌中的疗效和毒副反应。方法:采用如下方案治疗晚大肠癌:奥沙利铂85mg/m2ivgtt2hd1,亚叶酸钙400mgivgtt2hd1,5氟尿嘧啶2600mg/m2civ46h,每2周重复。结果:在可评价的26例患者中,完全缓解1例、部分缓解9例、稳定6例、疾病进展10例。全组有效率38.5%(10/26),至疾病进展时间4.3个月,1年生存率66.3%。毒副反应主要是恶心呕吐、手足麻木和静脉炎,程度均较轻。结论:奥沙利铂联合5氟尿嘧啶和亚叶酸钙双周方案治疗晚期大肠癌疗效确切,毒副反应低。Objective:To evaluate the efficacy and adverse effects of oxaliplatin combined with 5-fluororacil and folinic acid in treatment of advanced colorectal cancer. Methods:The patients were treated with oxaliplatin 85mg/m^2 iv infusion for 2h d1 combined with folinic acid 400mg iv infusion for 2h followed by 5-fluororacil 2 600mg/m^2 continuos-infusion for 46 h every 2 weeks.Gransetron was given to the patients to prevent nausea and vomiting d1 to d2. Results:Among the cases, 26 were evaluable .One patient showed a complete response ,9 did partial response, 6 did stable disease, and 10 did progression.The response rate was 38.5% .The time to progression was 4.3 months and the survival rate of one year was 66.3%. Conclusion:It is concluded that the combination schedule may be of value in the treament of advanced colorectal caner.

关 键 词：奥沙利铂 大肠癌 化疗 

分 类 号：R735.34[医药卫生—肿瘤]