肿瘤坏死因子相关凋亡诱导配体与肿瘤免疫  

Tumor necrosis factor-related apoptosis-inducing ligand and tumor immunity

作　　者：余丽梅[1] 陈代雄 周岐新[3] 

机构地区：[1]遵义医学院药理学教研室 [2]贵州省细胞工程实验室,贵州遵义563003 [3]重庆医科大学药理学教研室,重庆400016

出　　处：《中国药理学通报》2005年第6期657-661,共5页Chinese Pharmacological Bulletin

摘　　要：TRAIL是肿瘤坏死因子超家族成员,广泛表达于多种组织细胞。TRAIL与其受体结合后,可启动信号转导,选择性地诱导肿瘤细胞凋亡,而对正常细胞毒性小或无损伤。一些药物和细胞因子可协同TRAIL诱导肿瘤细胞凋亡。但肿瘤细胞也可通过表达TRAIL,产生免疫逃逸或免疫赦免,且TRAIL的作用还受到NFκB或靶细胞表达TRAIL受体类型和数量的影响。Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a member of the tumor necrosis factor (TNF) superfamily.It is extensively expressed on different tissues and cells. TRAIL can initiate singnaling through binding to TRAIL receptors. TRAIL selectively induces apoptosis of a variety of tumor cells, but has less toxition or no damage to most normal cells. TRAIL treatment in combination with chemotherapy drugs and cytokines can induces apoptosis of tumor cells. But a tumor emerges immune escape or immune privilege by expressing TRAIL on itself. The action of TRAIL is influenced by NF-κB or type and amount of TRAIL receptors on target cell.

关 键 词：TRAIL TRAIL受体 凋亡 肿瘤 

分 类 号：R-05[医药卫生] R329.25