花生四烯酸通过激活钙通道系统阻断饱和脂肪酸对血管内皮细胞的毒性作用  

Via activation of calcium channel system arachidonic acid protects ECV-304 endothelial cells against lipotoxicity induced by saturated fatty acids

作　　者：肖彧君[1] 母义明[1] 詹晓蓉[1] 李明[1] 陆祖谦[1] 陆菊明[1] 潘长玉[1] 

机构地区：[1]解放军总医院内分泌科,北京100853

出　　处：《中华内分泌代谢杂志》2005年第3期269-270,共2页Chinese Journal of Endocrinology and Metabolism

摘　　要：用各种阻断剂分别与饱和脂肪酸、花生四烯酸(AA)脂氧化酶和环氧化酶抑制剂处理血管内皮细胞,发现AA的脂氧化酶代谢物通过激活钙通道系统抑制软脂酸对血管内皮细胞的脂毒性作用。ECV-304 cells were treated separately with saturated free fatty acids, arachidonic acid (AA) and lipoxygenase and cyclooxygenase inhibitors for 48h. Via activating calcium channel system AA metabolites of lipoxygenase were able to protect ECV-304 cells against lipotoxicity induced by palmitic acid.

关 键 词：花生四烯酸 钙通道系统 饱和脂肪酸 血管内皮细胞 毒性作用 高脂血症 

分 类 号：R587.2[医药卫生—内分泌]