EXPRESSION AND CLINICAL SIGNIFICANCE OF E2F-3 AND Bc1-2 IN HEPATOCELLULAR CARCINOMA  

作　　者：鞠新华 张激扬 夏振龙 

机构地区：[1]Department of General Surgery, The Second Affiliated Hospital, China Medical University, Shenyang 110004 [2]Department of Surgery, The 463 Hospital of PLA, Shenyang 110042

出　　处：《Chinese Journal of Cancer Research》2005年第2期117-120,共4页中国癌症研究（英文版）

摘　　要：Objective: To investigate the expression of E2F and Bc1-2 and the clinicopathological significance in hepatocellular carcinoma. Methods: The expressions of E2F-3 and Bc1-2 in 74 patients with hepatic carcinoma, paracarcinoma and 15 patients with liver cirrhosis were detected by S-P immunohistochemical staining. Results: The expression of E2F in hepatic carcinoma was significantly higher than that in paracarcinoma or liver cirrhosis (P<0.005), the expression of Bc1-2 in hepatic carcinoma was significantly higher than that in paracarcinoma (P<0.005), in which Bc1-2 expression was lower than in liver cirrhosis(P<0.05). The expression of E2F-3 was related with histological grade, tumor size, and the expression of Bc1-2 was related with histological grade, tumor size and tumor number. There was correlation between the expression of E2F-3 and Bc1-2 in hepatic carcinoma. Conclusion: E2F-3 and Bc1-2 expression may play an important role in development, progression and cell apoptosis of tumor.Objective: To investigate the expression of E2F and Bc1-2 and the clinicopathological significance in hepatocellular carcinoma. Methods: The expressions of E2F-3 and Bc1-2 in 74 patients with hepatic carcinoma, paracarcinoma and 15 patients with liver cirrhosis were detected by S-P immunohistochemical staining. Results: The expression of E2F in hepatic carcinoma was significantly higher than that in paracarcinoma or liver cirrhosis (P<0.005), the expression of Bc1-2 in hepatic carcinoma was significantly higher than that in paracarcinoma (P<0.005), in which Bc1-2 expression was lower than in liver cirrhosis(P<0.05). The expression of E2F-3 was related with histological grade, tumor size, and the expression of Bc1-2 was related with histological grade, tumor size and tumor number. There was correlation between the expression of E2F-3 and Bc1-2 in hepatic carcinoma. Conclusion: E2F-3 and Bc1-2 expression may play an important role in development, progression and cell apoptosis of tumor.

关 键 词：E2F-3 BC1-2 Hepatocellular carcinoma Immunohistochemical staining 

分 类 号：R735.7[医药卫生—肿瘤]