无痛型心肌梗死与低血钠  

Painless myocardial infarction and hyponatremia

作　　者：沙立人[1] 

机构地区：[1]北京协和医院心内科,北京100032

出　　处：《中国临床保健杂志》2005年第3期195-197,共3页Chinese Journal of Clinical Healthcare

摘　　要：目的探讨无痛型急性心肌梗死(心梗)与低血钠的关系,无痛的机理及临床意义。方法对比心梗疼痛组与无痛组之间的血钠水平、住院病死率及伴发病,并求取低钠率和无痛率随年龄增长之间的相关系数。结果无痛组入院首次血钠水平明显低于疼痛组(P<0.01);无痛组住院病死率大于疼痛组(P<0.01);无痛组的糖尿病和慢性支气管炎伴发率大于疼痛组(P<0.01和P<0.05);患者低钠率与无痛率均与年龄增长呈正相关r=0.987(P<0.01)和r=0.996(P<0.01)。结论无痛型心梗与低血钠具有内在联系,受体构象可为此提供解读;纠正低钠血症可挽救更多的生命。Objective To approach the relationship of painless AMI and hyponatremia,mechanism of analgesia on molecular level,and clinical significances.Methods Pain group and pailess group were compared in levels of serum sodium,rates of hospitalized mortalities,rates of concomitant diseases.Corelative coefficients of low blood rate and painless rate with ageing were calculated.Results The initial sodium level of painless group was lower than that of pain group(P< 0.01 ).The hospitalized mortality of painless group was higher tnan that of pain group(P<0.01),as well as the comcomitant rates of diabetes mellitus and chronic bronchitis(P<0.01 and P<0.05).Both hyponatremia rate and painless rate had totally positive correlation with advancing ages,r=0.987 (P<0.002) and r=0.996(P<0.01).Conclusions There is a inner correlation between painless AMI and hyponatremia,that could be explained by the act of receptor comformations.Correcting the condition of hyponatremia will make more patients survived.

关 键 词：心肌梗死 低钠血症 蛋白质构象 

分 类 号：R542.22[医药卫生—心血管疾病]