氟西汀对急性脑梗死并发抑郁老年患者缺损神经功能的影响  

The effect of antideprssant (fluoxetine) on the defective nervous function of acute brain in farction complicated with depression in aged patieats

作　　者：童慧[1] 宋文英[1] 梁冰[1] 

机构地区：[1]蚌埠医学院附属医院老年病科,233004

出　　处：《中国临床保健杂志》2005年第3期215-216,共2页Chinese Journal of Clinical Healthcare

摘　　要：目的评价抗抑郁剂(氟西汀)的使用对急性脑梗死并发抑郁的老年患者缺损神经功能恢复的影响。方法60例患者分为三组:HAMD评分小于7分20例分为无抑郁组,余HAMD评分大于7分的40例随机分为治疗组和对照组。治疗前后按1995年通过的脑卒中患者临床神经功能缺损程度评分标准(CSS)及汉密顿抑郁评分量表(HAMD)17版进行评分。结果治疗后,治疗组HAMD分值较对照组低,两者相比有显著性差异(P=0.010)。治疗前后CSS评分差值非抑郁组最高,对照组最低,三者相比有显著性差异(P=0.000)。结论抑郁情绪不利于脑梗死患者缺损神经功能的恢复。早期进行药物抗抑郁治疗不仅有助于情绪恢复正常,也利于缺损神经功能的恢复。Objective To evaluate the effects of post ischemic stroke depression in the elderly and antidepressant(prozac) therapy on the improvement of motor scores and disability.Methods 60 patients were subdivided three groups:20 non-depressed ischemic stroke patients,and 40 depressed patients with ischemic stroke who had been treated (n=20) or not treated (n=20) with prozac.Depression severity was assessed with the Hamilton Rating Scale.Stroke severity was assessed with the China stroke neurological function impairment score(1995)(CSS) and the Hamilton Rating Scale.Results Neither the severity of baseline depression nor baseline scores obtained with CSS were different in treated and untreated depressed patients,but a better recovery from depression in the treated with prozac than that in the untreated group (P<0.05).Conclusions Depression after ischemic stroke in the elderly has negative effects on nervous functional recovery,and a pharmacological treatment of depression can counterbalance this effect.

关 键 词：抗抑郁药 脑梗死/并发症 抑郁症 老年人 

分 类 号：R749.1[医药卫生—神经病学与精神病学]