少突胶质细胞与缺血性脑损伤  

Oligodendrocytes and Ischemic Brain Injury

作　　者：陈应柱[1] 包仕尧[1] 田野[1] 

机构地区：[1]苏州大学附属第二医院神经内科,215004

出　　处：《国外医学（脑血管疾病分册）》2005年第5期367-370,共4页Foreign Medical Sciences Cerebrovascular Diseases

基　　金：江苏省卫生厅重大科研课题(No.k2000406)

摘　　要：少突胶质细胞是中枢神经系统的成髓鞘胶质细胞,在许多神经系统疾病中对损伤具有易损性。与神经元一样,少突胶质细胞对缺血性损伤有高度敏感性,其损伤机制包括氧化应激、兴奋性氨基酸和凋亡通路激活。了解少突胶质细胞的死亡机制有可能为白质缺血损伤后结构和功能的保存与修复提供新的治疗策略。The oligodendrocyte, myelin-forming glial cells of the central nervous system, is vulnerable to damage in a variety of neurologic diseases. Like neurons, oligodendrocytes are highly sensitive to injury by oxidative stress, excitatory amino acids, and activation of apoptotic pathways. Understanding mechanisms of oligodendrocyte death may suggest new therapeutic strategies to preserve or restore white matter function and structure after ischemic insults.

关 键 词：少突胶质细胞 缺血性脑损伤 氧化应激 细胞凋亡 受体拮抗剂 

分 类 号：R743[医药卫生—神经病学与精神病学]