抑癌基因PTEN在涎腺癌组织中的表达  

Expression of Tumor Suppressor Gene PTEN in Salivary Gland Carcinoma

作　　者：朱传凤[1] 周健[1] 何家才[1] 陈乔尔[1] 王银龙[1] 王元银[1] 杨魁[1] 

机构地区：[1]安徽医科大学口腔医学院,安徽合肥230032

出　　处：《口腔颌面外科杂志》2005年第2期134-136,169,共4页Journal of Oral and Maxillofacial Surgery

基　　金：安徽省教育厅基金资助项目(2004156)

摘　　要：目的:研究PTEN在正常涎腺组织及涎腺癌中的表达及意义。方法:应用免疫组化S鄄P法分别检测8例正常涎腺组织,24例粘液表皮样癌,26例腺样囊性癌中PTEN蛋白的表达。结果:PTEN蛋白在正常涎腺组织及涎腺癌中表达率分别为87.5%、22%,差异有显著性意义(P﹤0.05)。PTEN在高、中分化组粘液表皮样癌高表达率为35.3%,低分化组为28.5%,差异无显著性意义(P>0.05)。腺样囊性癌中PTEN蛋白表达率低于粘液表皮样癌,差异有显著性意义(P﹤0.05)。结论:提示PTEN蛋白与涎腺癌的发生、发展密切相关,PTEN蛋白表达与涎腺癌组织类型有相关性,而与组织学分级无明显相关性。Objective: To study the expression and significance of PTEN in normal salivary gland and salivary gland carcinoma. Methods: The expression of PTEN in 8 normal salivary gland, 24 mucoepidermoid carcinoma, and 26 adenoid cystic carcinoma were detected by immunohistochemical S-P assay. Results: The expression rate of PTEN in normal salivary gland and salivary gland carcinoma were 87.5% and 22% respectively. It was significantly associated with histological grade (P<0.05). Positive rates of PTEN was 35.3% in high and middle-differentiated mucoepidermoid carcinomas, positive rates of PTEN was 28.5% in low-differentiated mucoepidermoid carcinomas. It was not significantly associated with histological grade (P>0.05). The PTEN protein expression rate in adenoid cystic carcinoma was significantly lower than that in mucoepidermoid carcinoma. It was significantly associated with histological grade (P<0.05). Conclusion: PTEN protein plays a key role in the salivary gland carcinoma genesis and development. Expression of PTEN protein is not related to histological grade and is well related to salivary gland carcinoma.

关 键 词：抑癌基因PTEN 腺癌组织 正常涎腺组织 粘液表皮样癌 PTEN蛋白 免疫组化S-P法 腺样囊性癌 蛋白表达率 组织学分级 涎腺癌 显著性 组织类型 相关性 表达及 中分化 低分化 

分 类 号：R739.8[医药卫生—肿瘤]