糙皮侧耳真菌糖肽对人肿瘤浸润淋巴细胞杀伤活性的调节作用  

The Regulation Effect of POGP on the Killing Activity of Tumor In-filtration lymphocyte

作　　者：张玲[1] 韩玉美[1] 肖东杰[1] 董洪涛[1] 王芸[1] 毛海婷[1] 李华[1] 

机构地区：[1]山东省医学科学院基础所免疫室,山东医科大学生化制药教研室

出　　处：《药物生物技术》1994年第2期19-21,共3页Pharmaceutical Biotechnology

摘　　要：本实验从临床癌性胸腹水中分离获得肿瘤浸润淋巴细胞（ＴＩＬ），经ｒＩＬ－２诱导培养后杀伤活性明显增高，在培养系中加入ＰＯＧＰ，当培养５～１０天时，ＴＩＬ杀伤活性为８５．５０％，比对照组的６６．８０％有显著增高，且在培养的２０天内，保持较高的杀伤活性。umor infiltratiOn lymphocyte(TIL)was separated from malignant ascites and pleural effusion,Afterincabation with rIL-2 its killing activity increased obviously,and reached the top at incabetion 5-6days,and then decreased grad ually. Adding POGP into the culture system,the killing activity of TIL atincabation 5-10 days was 85.5%,higherthan that of the control(66.86%)obviously,and main-tained heigher killing activity within 20 days.

关 键 词：抗肿瘤活性 糙皮侧耳 真菌糖肽类 TIL细胞 

分 类 号：R730.51[医药卫生—肿瘤] R977.6[医药卫生—临床医学]