前列环素及血栓素在实验性肝肾综合征发病中的作用  

ROLES FOR PROSTAGLANDIN I2 AND THROMBOXANE A2 IN EXPERIMENTAL HEPATORENALSYNDROME

作　　者：王蕊[1] 尹镭[1] 李春梅 赵元昌[1] 马学惠[1] 

机构地区：[1]山西医学院肝病研究所

出　　处：《肝脏病杂志》1994年第4期210-212,共3页

摘　　要：采用硫代乙酰胺复制大鼠急性肝功能衰竭模型，结果大鼠在出现内毒素血症（ＥＴＭ）的同时，肾功能有明显异常，尿中ＰＧＩ２、ＴＸＡ２及其比值均有异常改变，提示ＥＴＭ的产生与肾脏ＴＸＡ２增多密切相关；ＥＴＭ及ＴＸＡ２均与肾小球滤过率（ＧＦＲ）下降有关。而丹参的防治作用似乎并非仅通过改变ＰＧＩ２、ＴＸＡ２产量及其比值这一单一途径。Thioacetamide (TAA)was used to induce the model of acute hepatic failure in rat.The results indicatedthat TAA-treated rats,all accompanied endotoxaemia(ETM),exhibited significant renal disorder and obviousabnormalities in urinary excretion of PGI2,TXA2 and their ratio.It pointed out that there was a close relation-ship between endotoxaemia and elevated TXA2 in renal,meanwhile the abnormdities of both ETM and TXA2related to the reducing of glomerular filtration rate.The effects of Radix Salviae Miltiorrhizae(RSM ) seemsnot to be only by changing excretions of PGI2,TXA2 and their ratio.

关 键 词：肝肾综合征 血栓素A2 前列环素 病理学 

分 类 号：R575.06[医药卫生—消化系统] R692.02[医药卫生—内科学]