肾缺血再灌注损伤对磺胺嘧啶代谢动力学的影响  

Influence of Renal Ischemia-reperfusion Injury on the pharmacokinetics of Sulfadiazine

作　　者：姚丹丹[1] 唐高兴[1] 

机构地区：[1]广州医学院从化学院生理教研室,广东从化510925

出　　处：《广州医学院学报》2005年第2期23-25,46,共4页Academic Journal of Guangzhou Medical College

摘　　要：目的:观察家兔肾缺血再灌注损伤(ischemicreperfusioninjury,I/R)对磺胺嘧啶药动学的影响。方法:建立肾I/R模型,24只家兔随机分为3组,A组:假手术;B组:夹闭45min后再灌2h;C组:夹闭2h后灌注2h。于再灌注同时注射磺胺嘧啶,测定其分布半衰期t1/2α,消退半衰期t1/2β,并于不同时间点检测血清中的尿素氮(BUN)和肌酐(Cr)含量,同时观察大鼠形态学改变。结果:(1)C组的t1/2α和t1/2β明显延长,与A组及B组相比差异有显著性(P<005),其血清中BUN和Cr含量亦明显升高(P<0.05)。(2)B组t1/2α与假手术组差异无显著性,但t1/2β与假手术组相比明显延长(P<0.05)。结论:兔肾I/R使磺胺嘧啶在体内的分布及消除异常,以缺血2h更为明显。Objective:To observe the influence of renal ischemia-reperfusion injury on the pharmacokinetics of sulfadiazine (SD) in rabbit. Methods: Rabbit renal ischemia-reperfusion injury model was established by clamping one renal pedicle for 45 or 120 minutes before relaxing it for reperfusion of 2 hours. SD were administered intravenously at the beginning of reperfusion. 24 rabbits were divided into 3 groups randomly: Group A (sham operation), Group B (ischemia 45 minutes) and Group C (ischemia 120 minutes). Serum creatinine (Cr) and BUN levels were measured before clamping, before relaxing, and 45 or 120 minutes after reperfusion. The blood concentrations of SD were determined after 45 or 120 minutes of infusion, and then half-life (t~1/2αand t~1/2β) of SD was calculated. Results: In Group C, serum level of Cr, BUN and t~1/2α and t~1/2β of SD were all increased prominently compared with Group A or Group B (P<0.05). In Group B, however, only t~1/2α of SD was obviously increased when compared with Group A( P<0.05). Conclusions: The pharmacokinetics of SD may become abnormal, which may be related to the deteriorated renal functions caused by renal ischemia-reperfusion injury.

关 键 词：肾缺血再灌注 磺胺嘧啶 半衰期 家兔 

分 类 号：R363[医药卫生—病理学]