Gene polymorphism of alpha-2 macroglobulin in patients with Parkinson's disease  

作　　者：郝怡鑫 傅强 郭品娥 张建荣 沈茜 

机构地区：[1]Department of Laboratory Diagnosis, Changhai Hospital, Second Military Medical University [2]Department of Anesthesiology, General Hospital Of PLA

出　　处：《Journal of Medical Colleges of PLA(China)》2005年第3期175-177,共3页中国人民解放军军医大学学报（英文版）

摘　　要：Objective:To explore the relationship between polymorphism of α2-macroglobulin(A2M) gene and Parkinson’s disease(PD)in Han Nationality in Shanghai.Methods:The distributions of A2M gene polymorphism (a Val1000Ile in exon24, V/I)were detected in 66 PD patients and 120 healthy controls using polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP) method. Results:The I allelic frequency in A2M exon24 gene of PD patients(90.9%) was significantly lower than that of the healthy controls(96.3%)(OR=0.39,P=0.033),so was the I/I genotype(OR=0.32,P=0.015), especially in the patients more than 60 years old(OR=0.31,P=0.04).Conclusion:The I allele in exon24 of A2M gene might inhibit the onset of PD in Han Nationality in Shanghai.Objective:To explore the relationship between polymorphism of α2-macroglobulin(A2M) gene and Parkinson's disease(PD)in Han Nationality in Shanghai.Methods:The distributions of A2M gene polymorphism (a Val1000Ile in exon24, V/I)were detected in 66 PD patients and 120 healthy controls using polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP) method. Results:The I allelic frequency in A2M exon24 gene of PD patients(90.9%) was significantly lower than that of the healthy controls(96.3%)(OR=0.39,P=0.033),so was the I/I genotype(OR=0.32,P=0.015), especially in the patients more than 60 years old(OR=0.31,P=0.04).Conclusion:The I allele in exon24 of A2M gene might inhibit the onset of PD in Han Nationality in Shanghai.

关 键 词：Parkinson's disease α2-macroglobulin(A2M) GENE POLYMORPHISM 

分 类 号：R742.5[医药卫生—神经病学与精神病学]