NF-κB上调VEGF表达影响胃癌预后  

Effect of VEGF expression up-regulated by nuclear factor-KB prognosis of gastric carcinoma

作　　者：陈贵 于颖彦[2] 谢岳林 尹浩然 朱正纲 

机构地区：[1]嘉定南翔医院外科,上海市201802 [2]上海第二医科大学附属瑞金医院消化外科研究所,上海市200025 [3]上海第三医科大学附属瑞金医院消化外科研究所,上海市200025

出　　处：《世界华人消化杂志》2005年第11期1275-1277,共3页World Chinese Journal of Digestology

基　　金：上海市重点学科基金资助;No.SZD04002~~

摘　　要：目的:探讨胃癌内核转录因子κB(nuclearfactor-κB,NF-κB)活化对血管内皮生长因子(vascularendothelialRrowthfactor,VEGF)表达的影响及对预后的影响.方法:选择胃癌根治术切除标本41例,应用免疫组织化学方法测定NK-κB,VEGF及CD34的表达,检测结果与胃癌临床病理学多参数进行经统计分析.结果:NF-κB呈活化型型表达者占受检病例的68.3%,VEGF呈强阳性表达者占受检病例的70.73%.NF-κB活化型表达组与VEGF高表达组有较高一致性(κ=0.393,P=0.012).NF-κB与VEGF同时表达组微血管密度明显较NF-κB与VEGF同时阴性组高(P=0.000),NF-κB与VEGF同时表达组生存期明显短于NF-κB与VEGF同时阴性组(P=0.035).结论:胃癌细胞通过活化NF-κB信号通道促进VEGF高表达,从而影响肿瘤内微血管密度及预后.AIM: To investigate the up-regulation of vascular endothe-lial growth factor (VEGF) induced by the activation of nuclear factor-κB (NF-κB) and its effect on the prognosis of gastric carcinoma. METHODS: Forty-one gastric carcinoma specimens were obtained by surgery and the expression of NF-κB, VEGF and CD34 were detected in paraffin-embedded tissue sections by immunohistochemical method. RESULTS: NF-κB was activated and expressed in 68.3% (28/41) gastric carcinoma and VEGF was expressed in 70.7% (29/41). A significant correlation was found between NF-κB activation and VEGF expression(κ = 0.393, P = 0.012). The microvessel Density in co-expression of NF-κB and VEGF group was significantly higher than that in non-expression group (P= 0.000). The co-expression of NF-κB and VEGF group showed markedly poorer prognosis than that did in non-expression group (P= 0.035). CONCLUSION: The activation of NF-κB contributes to tumor angiogenesis in gastric carcinoma by up-regulation of VEGF, which results in a poorer prognosis.

关 键 词：NF-ΚB VEGF表达 预后 血管内皮生长因子 免疫组织化学方法 肿瘤内微血管密度 NF-KB活化 上调 factor 核转录因子 胃癌根治术 NK-κB 临床病理学 切除标本 CD34 统计分析 检测结果 阳性表达 信号通道 胃癌细胞 高表达 多参数 

分 类 号：R735.2[医药卫生—肿瘤]