奎硫平合并氯丙咪嗪治疗伴强迫症状的分裂症对照研究  

A Comparative study of Quetiapine Combinod with Clomipramine in Treatment of Schizophrenia with Obsessive-compulsive Symptoms.

作　　者：张玉娟[1] 蒋玉卉[1] 赵淑芹[1] 方润领[1] 马建东[1] 

机构地区：[1]中国.河南省精神病医院,新乡,453002

出　　处：《中国健康心理学杂志》2005年第4期260-262,共3页China Journal of Health Psychology

摘　　要：目的了解奎硫平合并氯丙咪嗪治疗伴强迫症状的分裂症的疗效和副反应。方法对伴强迫症状的分裂症随机分为研究组和对照组,分别用奎硫平(国产)合并氯丙咪嗪、氯氮平合并氯丙咪嗪治疗8周。用PANSS、Y—BOCS评定疗效,用TESS评定副反应。结果研究组PANSS、Y—BOCS总分和各因子分与治疗前比较明显下降(P<0.01),与对照组相近(P>0.05);两组治疗后分裂症、强迫症状有效率、显效率、痊愈率、总有效率和总显效率结果无显著性差异(P>0.05);研究组治疗后TESS总分显著低于对照组(P<0.05)。结论奎硫平合并氯丙咪嗪治疗伴强迫症状的分裂症疗效肯定,副反应较轻,可作为治疗伴强迫症状分裂症的一个较好选择。ive Objective To understand the efficacy and side effects of quetiapine combined with clomiprapine in the treatment of with schizophrenia obsessive-compulsive symptoms. Methods The schizophrenic patients with obsessive-compulsive symptoms were randomly divided into experimental and control group receiving domestic quetiapine combined with clomiprapine and clozapine combined with clomiprapine for 8 weeks respectively. PANSS, Y-BOCS and TESS scales were used to measure their efficacy and side effects. Results The total scores of PANSS, Y-BOCS and other scores significantly decreased after treatment in study group (P<0.01), both groups had a similar effects (P>0.05); there were no significant difference among improvement, response, recovery rate, total improvement rate and total response rate in the treatment of schizophrenia with obsessive-compulsive symptoms between two groups (P>0.05); the total scores of TESS in study group was significant lower than that in controlled group (P<0.05). Conclusion The study suggests that combination of quetiapine and clomiprapine is effective and flesser side effects and a better choice in the treatment of schizophrenia with obsessive-compulsive symptoms.

关 键 词：伴强迫症状 氯丙咪嗪 分裂症 奎硫平 对照研究 PANSS 显著性差异 对照组 总有效率 副反应 治疗后 显效率 疗效 氯氮平 治疗前 因子分 痊愈率 

分 类 号：R749.305[医药卫生—神经病学与精神病学] R749.4[医药卫生—临床医学]