兔角膜碱烧伤后不同时期的组织病理学变化  

Changes of rabbit corneal histopathology at different stages after alkali burns

作　　者：郑晓汾[1] 冯克孝[1] 李冰[1] 杨纪忠[1] 葛京京[1] 

机构地区：[1]山西省眼科医院角膜科,中国山西省太原市030002

出　　处：《国际眼科杂志》2005年第3期449-450,共2页International Eye Science

摘　　要：目的:通过动物角膜碱烧伤模型,观察烧伤后不同时期角膜组织病理学的变化。方法:新西兰白兔36只,制作角膜中央部中度碱烧伤模型并依据取材时间完全随机分为12组:分别于烧伤后1,2,3,5,7d;2,3,4,5,6,7,8wk取材,做光镜、电镜观察。结果:角膜碱烧伤后1wk内上皮即修复,但2～3wk再次脱落,炎症细胞2wk后开始浸润,中期PMN较多,晚期淋巴细胞较多。结论:角膜碱烧伤后碱性物质的直接损害,MMP,及免疫反应均参与了对角膜的损害。· AIM: To observe the changes of rabbit corneal histopathology at different stages after alkali burns.· METHODS: Thirty-six male New Zealand rabbits with alkali burned eyes were randomly divided into 12 groups. The corneal structure at different stages after alkali burns is observed by light and electron microscopy. · RESULTS: The epithelium was recovered within 1wk but desquamated at 2 or 3wk. The corneal stroma was infiltrated by inflammative cells, including PMN that appeared mostly at the middle stage and lymphocyte that appeared mostly at the late stage.· CONCLUSION: The direct damage of alkali materials, MMP and immune reaction were all involved in the damage of cornea after alkali burns.·

关 键 词：兔 碱烧伤 组织病理学 角膜组织 眼科 

分 类 号：R779.1[医药卫生—眼科]