散发性戊型病毒性肝炎394例临床分析  

A Clinical Analysis of 394 Patients with Sporadic Viral Hepatitis E

作　　者：马科[1] 肖非[1] 许东[1] 田德英[1] 

机构地区：[1]华中科技大学同济医学院附属同济医院,武汉430030

出　　处：《内科急危重症杂志》2005年第3期133-135,共3页Journal of Critical Care In Internal Medicine

摘　　要：目的:探讨武汉地区散发性戊型病毒性肝炎(HE)的临床特点及其预后。方法:对经血清学检测证实的394例HE患者进行分析。结果:临床上HE以散发形式发病为主,各种慢性肝病患者重叠感染HEV168例,相当常见(42.64%),其病死率(16.07%)明显高于单纯HE组(6.10%)(P<0.01)。老年(≥60岁)患者98例(24.87%),老年组HE患者黄疸高,持续时间长,平均病程为(36.3±4.0)d,较非老年组(24.4±2.3)d,明显延长(P<0.01);老年组并发症发生率(47.95%)明显高于非老年组(28.57%)(P<0.01);老年组重型肝炎发生率(22.45%)及病死率(13.33%)明显高于非老年组(9.18%)(P<0.05)及(5.33%)(P<0.01)。结论:HE发病率呈逐年增高趋势,慢性肝病重叠感染HEV及老年HE患者的病死率高,应引起重视。Objective:To investigate the clinical features and prognosis of sporadic Hepatitis E patients in Wuhan district. Methods:To analyze 394 patients with Hepatitis E which were confirmed by serodiagnosis . Results: The Hepatitis E was predominantly sporadic. Patients with different chronic liver diseases superinfected with HEV(168) were frequent ( 42.64%),the mortality in the superinfection group( 16.07%) were higher than that in the simple group ( 6.10%)(P< 0.01). There were 98 elderly(≥60 years) patients ( 24.87%). In the elderly group ,jaundice was deeper and lasted longer(P< 0.01), the average course was longer in the elderly group( 36.3± 4.0)d than that in the control group 24.4± 2.3d. The incidence of complication in the elderly group( 47.95%)was higher than that in the control group( 28.57%)(P< 0.01). The elderly group had a higher fulminant hepatitis rate( 22.45%)and higher mortality ( 13.33%) than that in the control group( 9.18%)(P< 0.05)and ( 5.33%)(P< 0.01).Conclusion: The occurrence rate of hepatitis E was increased yearly.Patients with chronic liver diseases who were superinfected with HEV and the elderly people who suffered from hepatitis E show much higher mortality.

关 键 词：戊型病毒性肝炎 重叠感染 老年 

分 类 号：R575.1[医药卫生—消化系统]