甲基-苯基-四氢吡啶增加脑糖代谢与Deprenyl对其拮抗作用的实验研究  

Increase of Regional Cerebral Glucose Metabolism Induced by Methyl-Phenyl-Tetrahydropyridine (MPTP) and Prevented by Deprenyl: An Experimental Study

作　　者：陈生弟[1] 徐德隆 周孝达[2] 钱可久[2] 

机构地区：[1]上海第二医科大学瑞金医院神经科,200025 [2]上海第二医科大学仁济医院神经科,200001

出　　处：《临床神经科学》1994年第4期201-203,共3页Chinese Journal of Clinical Neurosciences

摘　　要：应用[~3H]2-脱氧葡萄糖(2-DG)放射自显影法观察单胺氧化酶B型(MAO-B)抑制剂Deprenyl和神经毒素甲基-苯基-四氢吡啶(MPTP)对小鼠脑2-DG摄取的影响。腹腔注射MPTP后,模型组鼠的黑质和蓝斑区的2-DG摄取量较对照组鼠明显增加,并表现出明显的行为异常反应。预先口服Deprenyl的拮抗组鼠,2-DG摄取量与对照组相同,且行为反应轻微。结果表明MPTP对小鼠黑质和蓝斑区的局部糖利用有明显影响;Deprenly能有效防止MPTP的这一有害作用。3H-2-deoxyglucose (2-DG) autoradiographic technique was used to study the effects of a monoamine oxidase-B (MAO-B) inhibitor deprenyl and the neurotoxin methyl-phenyl-tetra hy-dropyridine (MPTP) on 2-DG uptake in the mouse brain. Following MPTP intoxication, 2-DG uptake was increased in the substantia nigra and locus ceruleus. At the same time, obvious abnormal behavior of the animals was induced. In the mice pretreated with deprenyl, 2-DG uptake was similar to that of control animal. Abnormal behavior, though present, was significantly milder than that in mice given MPTP alone. It is concluded that MPTP interferes with the glucose metabolism in the substantia nigra and locus ceruleus and induces remarkable abnormal behavioral syndrome of mice. These deleterious effects can be blocked by pretreatment with deprenyl.

关 键 词：震颤麻痹 四氢吡啶 脑糖代谢 

分 类 号：R742.502[医药卫生—神经病学与精神病学]