子宫内膜样腺癌Bax与p53表达的意义  

Significance of Bax and p53 protein expression in endometrioid adenocarcinomas

作　　者：左春梅[1] 王华[1] 韩爽[1] 毛东伟[1] 杨怡卓[1] 丁钢 赵瑞波[3] 

机构地区：[1]解放军第211医院妇产科 [2]医院中心实验室 [3]哈尔滨医科大学病理教研室,哈尔滨150080

出　　处：《中国优生与遗传杂志》2005年第6期26-26,30,共2页Chinese Journal of Birth Health & Heredity

摘　　要：目的探讨Bax和p53蛋白在子宫内膜样腺癌发生、发展中的作用。方法通过免疫组化SP法检测49例子宫内膜样腺癌石蜡标本的Bax和p53蛋白表达。结果子宫内膜样腺癌组和对照组Bax表达率分别为44.9%和77.1%(P<0.05)。p53蛋白在对照组无表达,在子宫内膜样腺癌组13例表达阳性(26.5%),p53阳性率及表达强度与细胞分化不良相关。结论子宫内膜样腺癌Bax表达减少,可能导致线粒体介导的凋亡过程减弱,p53过度表达提示细胞的恶性程度高和预后不良。Objective: To investigate the roles of Bax and p53 proteins in the pathogenesis of endometrioid adenocarcinoma. Methods:Immunohistochemical staining was used for detecting Bax and p53 in 49 paraffin samples diagnosed as endometrioid adenocarcinoma pathologically.Results: 44.9%(22/49) of the samples were Bax positive in endometrioid adenocarcinoma compared with 77.1%(27/35) in control(P<0.05). Control showed p53 negative, apparently different from 26.5% (13/49) of positive staining in endometrioid adenocarcinoma, and enhanced strength of p53 expression was correlated to poorly differentiated cells. Conclusions:Reduced expression of Bax is involved in the cancer mechanism and overexpression of p53 implicates poor differentiation and prognosis in endometrioid adenocarcinoma.

关 键 词：子宫内膜癌 腺癌 蛋白质BAX 蛋白质P53 细胞凋亡 

分 类 号：R737.33[医药卫生—肿瘤]