煤焦沥青烟气诱发小鼠前胃肿瘤的研究  

Study on the mouse forestomach neoplasms induced by coal tar pitch smoke

作　　者：王江[1] 赵庆夏[1] 魏丽[1] 李新荣[1] 张红新[1] 

机构地区：[1]河南医科大学病理学教研室

出　　处：《河南医科大学学报》1994年第1期4-6,F003,共4页Journal of Henan Medical University

基　　金：河南省教委自然基金

摘　　要：１００只昆明种小鼠随机分为两组。Ａ组小鼠每ｄ在一密闭柜中吸入煤焦沥青烟气３ｈ，共吸入４个月。柜内烟气平均浓度为０．１７ｍｇ／Ｌ。Ｂ组为空白对照。实验持续８个月，其中于第３和第６个月时，每组各处死动物６只，最后将剩余动物全部处死。８个月中，Ａ组小鼠前胃肿瘤发生率达７２．５０％（２９／４０），其中有７例鳞癌（１７．５０％），其余为乳头状瘤。研究提示：煤焦油沥青有强烈的致小鼠前胃肿瘤作用，可能是诱发食管癌的潜在危险因素。Kuming mice were divided at random into two groups.The mice in group A inhaled coal tar pitch smoke(CTPS)in a sealed box 3 hours a day for 4 months.The average concentration of CTPS in the box was 0.17mg/L.Group B was taken as control.The whole experiment lasted for 8 months.6mice in each group were killed respectively on the third and the sixth month,and the rest were killed at the end of the experiment.The incidence of mice forestomach neoplasm in group A was 72.50%(29/40).There were 7 squamous cell carcinomas(17.5%)among them and the rest,papiollomas.The study suggests that CTPS might have strong tumorigenic effect on the forestomach of mouse and might be a potential carcinogenic factor to the esophagus.

关 键 词：煤焦沥青 小鼠 胃肿瘤 诱发 

分 类 号：R735.202[医药卫生—肿瘤]