人脑胶质瘤中Cyclin D1、P16蛋白的表达及相关性研究  

A study of the expression of Cyclin D1,P16 gene protein and the correlatio between them in brain gliomas

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作  者:邢洲[1] 曾白云[1] 岑宇翔[1] 

机构地区:[1]广州医学院第二附属医院神经外科,510260

出  处:《广州医药》2005年第4期7-10,共4页Guangzhou Medical Journal

摘  要:目的检测不同级别胶质瘤中CyclinD1、P16蛋白的表达,探讨二者在胶质瘤恶性程度以及预后的预测方面的意义。方法通过SP法免疫组化检测人脑胶质瘤中CyclinD1、P16蛋白的表达水平,并分析相关性。结果低级别胶质瘤与高级别胶质瘤两组的CyclinD1、P16蛋白阳性率有显著差异。复发组、死亡组与未复发组、未死亡组的CyclinD1阳性、P16蛋白阳性率有显著差异。结论CyclinD1与P16蛋白的表达水平对预测脑胶质瘤恶性程度与预后有重要意义。Objective We determined the expression of Cyclin D1 and P16 protein in glioma to investigate the value of them in evaluating malignancy and predicting prognosis. Methods This experiment determined the expression of Cyclin D1 and P16 protein by S-P immunohistochemical analysis,and discuss the correlation between them. Results The difference of the Cyclin D_1 positive ratio and P16 protein positive ratio in the low grade glioma and high grade glioma are significant.The differerence of the Cyclin D1 positive ratio and P16 protein positive ratio in the relaps group、dead group and non-relaps group、survival group are significant. Conclusion The expression of Cyclin D1 and P16 protein is important in evaluating malignancy and prognosis of glioma patients.

关 键 词:Cyclin P16蛋白 人脑胶质瘤 相关性研究 表达及 免疫组化检测 低级别胶质瘤 恶性程度 S-P法 重要意义 阳性率 死亡组 预测 预后 水平 复发 

分 类 号:R739.4[医药卫生—肿瘤]

 

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