胃左动脉化疗栓塞联合放疗治疗晚期贲门癌30例临床观察  

Transarterial chemoembolization combined with radiotherapy in treatment of 30 cases with advanced cardiac carcinoma

作　　者：范才[1] 崔进国[1] 张建军[1] 徐莉[1] 孙兴旺[1] 于学林[1] 

机构地区：[1]白求恩国际和平医院放疗科,河北石家庄050082

出　　处：《临床荟萃》2005年第14期789-790,共2页Clinical Focus

摘　　要：目的探讨动脉化疗栓塞联合放射疗法治疗晚期贲门癌的疗效.方法晚期贲门癌患者67例,随机分为单放组和综合组,综合组30例,放疗前1周行胃左动脉化疗栓塞,然后给予靶区剂量(DT)60～65 Gy,6～7周照射;单放组37例,常规放疗DT70 Gy/7周,观察患者治疗效果及影像学改善情况,随访4～28月.结果综合组和单放组梗阻症状改善率分别为100%(30/30)及70.3%(26/37)两组差异有统计学意义(P＜0.01);X线好转率分别为86.6%(26/30)及70.3%(26/37)(P＞0.05);综合组和单放组患者1、2年生存率分别为80%(24/30)及56.8(21/37)(P＜0.05),40%(12/30)及29.7(11/37)(P＞0.05).结论动脉化疗栓塞结合放疗是一种治疗晚期贲门癌的有效方法.Objective To investigate the treatment effects of transarterial chemoembolization(TACE) combined with radiotherapy on advanced cardiac carcinoma. Methods Sixty-seven patients with advanced cardiac carcinoma were randomly divided into two groups: 30 patients were treated by TACE plus radiotherapy, the radiation dose was 60-65 Gy,for 6-7 weeks (TACE+R), 37 patients received radical radiotherapy alone(R), the radiation dose was 70 Gy,for 7 weeks. The patients were followed up within 4 to 28 months and the improvements of clinical symptoms and image on barium meal were observed. Results The improvements of clinical symptoms were 100%(30/30) in TACE+R and 70.3%(26/37) in R group, with an obvious difference between those two groups(P< 0.01). The improvements of obstruction on barium meal were 86.6%(26/30) in TACE+R and 70.3%(26/37) in R group (P> 0.05). The 1-,2-year survival rates were 80%(24/30) and 40%(12/30) in TACE+R, 56.8%(21/37) and 29.7%(11/37) in R group, with the difference in 1-year survival rate between those two groups (P< 0.05). Conclusion Radiotherapy combined with TACE was an effective method for advanced cardiac carcinoma.

关 键 词：胃肿瘤 化学栓塞 治疗性 放射疗法 

分 类 号：R735.2[医药卫生—肿瘤]