发作性睡病的临床监测与特征分析  

Clinical monitoring and characteristics in narcolepsy

作　　者：谭春英[1] 李冲[1] 杜好瑞[1] 王夏红[1] 杨福收[1] 

机构地区：[1]新乡医学院第二附属医院睡眠研究室,河南新乡453002

出　　处：《临床荟萃》2005年第13期731-733,共3页Clinical Focus

摘　　要：目的探讨多导睡眠图(ploysomnography;PSG)、多次睡眠潜伏期试验(multiplesleeplatencytest;MSLT)在发作性睡病(Narcolepsy;NC)和嗜睡症(lethargy;IH)患者诊断、鉴别诊断中的价值。方法对35例发作性睡病(NC)和30例嗜睡症(IH)进行整夜多导睡眠图(PSG)描记和多次睡眠潜伏期试验(MSLT),分析其睡眠参数异同。结果MSLT结果显示:NC组睡眠潜伏期和快动眼睡眠(REM)潜伏期显著缩短,入睡次数和REM睡眠出现次数明显多于IH组和对照组(P<0.01),睡眠潜伏期<5分钟和ROREMPs≥2次30例(85.7%),与IH组比较差异有统计学意义(P<0.01);整夜PSG结果显示:NC组总睡眠时间和深睡眠(SWS)百分比及REM潜伏期显著低于IH组和对照组,而S1阶段睡眠显著高于IH组,两组比较,差异具有统计学决心义(P<0.01)。结论NC患者具有明显的睡眠潜伏期缩短和反常的REM睡眠特征,MSLT、PSG对NC和IH的诊断和鉴别诊断具有重要参考价值。Objective To explore the values of the polysomnography(PSG) and multiple sleep latency test(MSLT) monitoring in diagnoses and differential diagnoses of narcolepsy(NC) and lethargy(IH). Methods Whole-night PSG and MSLT were conducted in 35 patients with NC and 30 with IH and sleep parameters analyzed. Results MSLT showed that latencies of sleep and rapid eye movement(REM) sleep significantly shortened, frequencies of REM occurrence and the rate of falling asleep were much more in NC group than in IH and control groups(P< 0.01);30( 85.7%) exhibited sleep latency<5 and ROREMPs≥2 times in NC group, which had obvious statistic significance compared with IH group ( P< 0.01); PSG showed that total sleep time, slow wave sleep percentage and REM latency were significantly lower in the NC group than in the IH and control groups, and S1 sleep was significantly higher than in the IH group(P< 0.01). Conclusion Patients with NC had significant shortened sleep latency and abnormal features of REM sleep, the MSLT and PSG were important reference to diagnoses and differential diagnoses of narcolepsy and lethargy.

关 键 词：发作性睡病 睡眠 快动眼运动 

分 类 号：R748[医药卫生—神经病学与精神病学]