食管癌根治术后预防性放射治疗随机研究的Meta分析  

The Meta-analysis of Randomized Controlled Trial of Prophylactic Radiotherapy for Esophageal Carcinoma after Curative Resection

作　　者：陆进成[1] 钱普东[1] 查文武[1] 张宜勤[1] 

机构地区：[1]江苏省肿瘤医院放疗科,南京210009

出　　处：《循证医学》2005年第3期166-168,171,共4页The Journal of Evidence-Based Medicine

基　　金：江苏省科委社会发展计划项目(BS2000065)

摘　　要：目的探讨食管癌根治术后预防性放射治疗的临床价值。方法通过PubMed、CHDL联机检索,主题词:食管癌、术后、放射治疗(放疗),出版类型限定:随机对照试验,手工检索中华放射肿瘤学会历届年会论文辑,对所得到的文献进行Meta分析。结果现有的证据(3篇前瞻性随机试验)尚不能肯定食管癌根治术后预防性放射治疗的优劣性(OR1.2552,95%CI0.6878～2.2908),但对淋巴结病理阳性患者进行预防性放射治疗可提高5年生存率(OR2.1988,95%CI1.3310～3.6324),“抽屉文件”数为5。结论食管癌根治性术后对病理淋巴结阳性患者进行预防性放射治疗可提高5年生存率。Objective To study the clinical value of prophylactic radiotherapy for esophageal carcinoma after curative resection. Methods The PubMed, CHDL were searched with no language restrictions, and limited to published types “randomized controlled trial”. Medical subject heading (MeSH) terms included “esophageal carcinoma” with the subheading “postoperative”, “radiotherapy”. The proceedings of the 1986,1990,1994 and 1999 annual meeting of the Chinese Society of Radiation Oncology were also searched by handwork. Evidence was evaluated with meta-analysis. Results Evidence from the only three randomized trials can not show the influence of prophylactic radiotherapy of esophageal carcinoma after curative resection (5-year survival odds ratio 1.255 2; 95% confidence interval 0.687 8～2.290 8), patients with lymph node involved, however, had a statistically significant survival benefit at 5 years after prophylactic radiotherapy, compared with surgery alone (5-year survival odds ratio 2.198 8; 95% confidence interval 1.331 0～3.632 4), file drawer analysis was 5. Conclusions Prophylactic radiotherapy is able to improve the survival of patients with lymph node involved after curative resection.

关 键 词：食管肿瘤/放射疗法 食管肿瘤/手术 META分析 

分 类 号：R735.1[医药卫生—肿瘤]